Low and high birth weight in a hospital population in Sudan: An analysis of clinical cut‐off values

Abdelrahiem, Somia K.; Bilal, Jalal Ali; Nafeesah, Abdullah Al; Al‐Wutayd, Osama; Rayis, Duria A.; Adam, Ishag

doi:10.1002/ijgo.13543

Cited by 3 publications

(3 citation statements)

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“…In this study, 12% of deliveries resulted in a LBW infant. The prevalence of LBW in our study is comparable with the LBW prevalence (14.3%) which was previously reported in the same hospital ( 20 ) and in different hospitals in neighboring Ethiopia ( 24 – 26 ). The prevalence of LBW in our study is lower than the LBW prevalence (21.6%) reported at the Debre Markos Hospital (Ethiopia) ( 27 ).…”

Section: Discussionsupporting

confidence: 90%

“…A sample size calculation for a cross-sectional study was applied and was estimated as 1,505 women using the recent prevalence (14.5%) of LBW in the study area ( 20 ). Thus, we assumed that the ratio of women with LBW to the women with no LBW was 1:6.…”

Section: Methodsmentioning

confidence: 99%

“…Several studies have assessed the association between birth weight/LBW and maternal undernutrition in African countries (15)(16)(17)(18)(19). LBW is a health problem in Sudan (20,21). It has been reported that 12.5% of pregnant Sudanese women in Khartoum are undernourished (22).…”

Section: Introductionmentioning

confidence: 99%

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Maternal Undernutrition and Low Birth Weight in a Tertiary Hospital in Sudan: A Cross-Sectional Study

et al. 2022

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BackgroundThe World Health Organization set a Global Nutrition Target of a 30% reduction in LBW by 2025. Maternal malnutrition/undernutrition is among the most important modifiable risk factors for impaired fetal growth. This study investigates the effect of maternal undernutrition on LBW in Sudan.MethodsA cross-sectional study was conducted at Saad Abuelela Hospital in Khartoum, Sudan, from May to October 2020. The sociodemographic and obstetric data of the women were gathered via questionnaire, and their mid-upper arm circumference (MUAC) was measured. Maternal undernutrition was defined as a MUAC of <23 cm.ResultsIn total, 1,505 pairs of pregnant women and their newborns were enrolled in the study. The medians [interquartile (IQR)] of the age, parity, and gestational age were 27.0 (9.0) years, 1.0 (3.0), and 38.0 (2.0) weeks, respectively. The median (IQR) of the birth weight was 3,028.0 (690.0) g. Of the 1,505 participants, 182 (12.1%) delivered LBW infants. Multivariate logistic regression showed that MUAC [adjusted odds ratio (AOR) = 0.91, 95% confidence interval (CI) = 0.87–0.96] and gestational age (AOR = 0.79, 95% CI = 0.73–0.85) were negatively associated with LBW. The level of antenatal care <2 visits (AOR = 2.10, 95% CI = 1.30–3.57) was associated with LBW. Women with undernutrition were at a higher risk of delivering LBW infants (AOR = 1.66, 95% CI = 1.09–2.53).ConclusionLBW is a health problem in Sudan, and women with undernutrition were at a higher risk of delivering LBW infants.

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Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

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Maternal Undernutrition and Low Birth Weight in a Tertiary Hospital in Sudan: A Cross-Sectional Study

et al. 2022

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Availability and affordability of cardiovascular medicines in a major city of Afghanistan in 2020

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A Novel Splice-Site Deletion in the POU1F1 Gene Causes Combined Pituitary Hormone Deficiency in Multiple Sudanese Pedigrees

Hassan

Abdullah

Podkrajšek

et al. 2022

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Pathogenic variants within the gene encoding the pituitary-specific transcription factor, POU class 1 homeobox 1 (POU1F1), are associated with combined pituitary hormone deficiency (CPHD), including growth hormone, prolactin, and thyrotropin stimulating hormone deficiencies. The aim of the study was to identify genetic aetiology in 10 subjects with CPHD from four consanguineous Sudanese families. Medical history, as well as hormonal and radiological information, was obtained from participants’ medical records. Targeted genetic analysis of the POU1F1 gene was performed in two pedigrees with a typical combination of pituitary deficiencies, using Sanger sequencing, and whole-exome sequencing was performed in the other two pedigrees, where hypocortisolism and additional neurologic phenotypes were also initially diagnosed. In POU1F1 gene (NM_001122757.2) a novel homozygous splice-site deletion—namely, c.744-5_749del—was identified in all 10 tested affected family members as a cause of CPHD. Apart from typical pituitary hormonal deficiencies, most patients had delayed but spontaneous puberty; however, one female had precocious puberty. Severe post-meningitis neurologic impairment was observed in three patients, of whom two siblings had Dyke–Davidoff–Masson syndrome, and an additional distantly related patient suffered from cerebral infarction. Our report adds to the previously reported POU1F1 gene variants causing CPHD and emphasises the importance of genetic testing in countries with high rates of consanguineous marriage such as Sudan. Genetic diagnostics elucidated that the aetiologies of hypopituitarism and brain abnormalities, identified in a subset of affected members, were separate. Additionally, as central hypocortisolism is not characteristic of POU1F1 deficiency, hydrocortisone replacement therapy could be discontinued. Elucidation of a genetic cause, therefore, contributed to the more rational clinical management of hypopituitarism in affected family members.

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Low and high birth weight in a hospital population in Sudan: An analysis of clinical cut‐off values

Cited by 3 publications

References 20 publications

Maternal Undernutrition and Low Birth Weight in a Tertiary Hospital in Sudan: A Cross-Sectional Study

Maternal Undernutrition and Low Birth Weight in a Tertiary Hospital in Sudan: A Cross-Sectional Study

Availability and affordability of cardiovascular medicines in a major city of Afghanistan in 2020

A Novel Splice-Site Deletion in the POU1F1 Gene Causes Combined Pituitary Hormone Deficiency in Multiple Sudanese Pedigrees

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