Low and atmospheric plasma polymerisation of nanocoatings for bio-applications

Bhatt, Sudhir; Pulpytel, Jérôme; Arefi‐Khonsari, Farzaneh

doi:10.1680/sufi.14.00008

Cited by 44 publications

(36 citation statements)

References 215 publications

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“…Of course, to further control release from the plasma coating -to get closer to the 2-3 month sustained release required for treatment of osteomyelitis -thicker layers need to be produced, as shown for coatings on polymer films by Arefi-Khonsari et al [36,37] or in our case in bioceramics from previous work [38]. In fact, a certain reduction in the release rate was recorded in the release of ampicillin from the coatings obtained at longer plasma treatment times (PP20-D, PP30-D and PP40-D) as had also been observed in a previous work of the group evaluating the same drug for coatings produced in similar conditions [20].…”

Section: Discussionmentioning

confidence: 99%

Plasma polymerized bioceramics for drug delivery: Do surface changes alter biological behaviour?

Khurana

Müller

Jacobs

et al. 2018

European Polymer Journal

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One of the treatments for recurrent or complicated osteomyelitis is by local antibiotherapy mediated by suitable bone grafts. β-Tricalcium Phosphate (β-TCP) bioceramic is a resorbable bone graft. Its microporosity allows for incorporation of drugs, but a too fast release is often obtained. Complex strategies have been explored to obtain controlled drug release. In this work, plasma polymerization of a biocompatible polymer was investigated on β-TCP. Polyethyleneglycol (PEG)-like polymer coatings of different thickness were deposited on microporous β-TCP loaded with antibiotics. A highly hydrophobic surface was obtained despite the hydrophilicity of the PEG-like layer produced, which was associated to the roughness of the β-TCP substrate. The bioceramics nevertheless retained their suitable biological behavior with regard to human osteoblast cells. The microbiological activity of the antibiotics was preserved, and the coatings reduced the total amount of drug released as a function of the increasing plasma treatment time.

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Section: Discussionmentioning

confidence: 99%

Plasma polymerized bioceramics for drug delivery: Do surface changes alter biological behaviour?

Khurana

Müller

Jacobs

et al. 2018

European Polymer Journal

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“…The deposition was performed with a DBD jet to overcome one of the main drawbacks of the most diffuse DBDs geometries (e.g., parallel plate or coaxial cylindrical geometries), which, due to the narrow gas gap, impose limitation in the size and shape of substrates that can be processed. 4,[80][81][82][83] However, it is worth mentioning that the optimization of deposition processes using plasma jets generally requires much effort, since many factors can affect the physical and chemical proprieties of the plasma plume. Moreover, in this specific case of study, to obtain water-stable coatings containing COOH groups using a DBD jet, we decided to act on the "input" chemistry of the deposition process (i.e., copolymerization of acrylic acid and ethylene), rather than on the electrical parameters of the discharge (e.g., increase of the input power to improve acrylic acid fragmentation and coating cross-linking).…”

Section: Dbd Jet Deposition Of Thin Films Containing Carboxylic Acid mentioning

confidence: 99%

Thin film deposition at atmospheric pressure using dielectric barrier discharges: Advances on three-dimensional porous substrates and functional coatings

Fanelli

Bosso

Mastrangelo

et al. 2016

Jpn. J. Appl. Phys.

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Surface processing of materials by atmospheric pressure dielectric barrier discharges (DBDs) has experienced significant growth in recent years. Considerable research efforts have been directed for instance to develop a large variety of processes which exploit different DBD electrode geometries for the direct and remote deposition of thin films from precursors in gas, vapor and aerosol form. This article briefly reviews our recent progress in thin film deposition by DBDs with particular focus on process optimization. The following examples are provided: (i) the plasmaenhanced chemical vapor deposition of thin films on an open-cell foam accomplished by igniting the DBD throughout the entire three-dimensional (3D) porous structure of the substrate, (ii) the preparation of hybrid organic/inorganic nanocomposite coatings using an aerosol-assisted process, (iii) the DBD jet deposition of coatings containing carboxylic acid groups and the improvement of their chemical and morphological stability upon immersion in water

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“…Plasma polymerization is a dry and single-step method that is solvent free [16]. Plasma (co-)polymerization of different organic monomers for surface modification with a variety of substrates has been used for tunable biomolecule-surface interactions and controlled drug delivery applications [17,18]. However, the inconvenience of this method has been reported by free-radical-induced grafting [19].…”

Section: Introductionmentioning

confidence: 99%

Multi-nanolayer drug delivery using radio frequency plasma technology

Iman

Baitukha

Pimpie

et al. 2020

Preprint

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Background: It may be impossible to perform cancer surgery with free margins in the presence of an unresectable structure. Local drug treatment after surgery has been proposed to increase the rate of tumor control. Methods: Multi-nanolayers (10-330nm) were generated by a low-pressure (375mTorr) inductively coupled plasma (13.56MHz) reactor for anticancer drug delivery by the deposition of polycaprolactone-polyethylene glycol multistack barrier on the collagen membrane (100µm thickness). Carboplatin (300µg/cm 2 ) was used for the in vitro and in vivo investigations. Energy-dispersive X-ray spectroscopy (15keV), scanning electron microscopy and inductively coupled plasma mass spectrometry were used to detect the presence of carboplatin in the nanolayer, the tumor sample and the culture medium. Preclinical studies were performed on ovarian (OVCAR-3NIH) and colon (CT26) cancer cell lines as xenografts (45 days) and allografts (23 days) in Swiss-nude (n=6) and immunocompetent BALB/cByJ mice (n=24), respectively. Results: The loading of carboplatin or other drugs between the nanofilm on the collagen membrane did not modify the mesh complex architecture or the drug properties. Drugs were detectable on the membrane for more than two weeks in the in vitro analysis and more than 10 days in the in vivo analysis. Cytotoxic mesh decreased cell adherence (down 5.42-fold) and induced cancer cell destruction (up to 7.87-fold). Implantation of the mesh on the mouse tumor nodule modified the cell architecture and decreased the tumor size (50.26%) compared to the control by inducing cell apoptosis. Conclusion: Plasma technology allows a mesh to be built with multi-nanolayer anticancer drug delivery on collagen membranes.

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Low and atmospheric plasma polymerisation of nanocoatings for bio-applications

Cited by 44 publications

References 215 publications

Plasma polymerized bioceramics for drug delivery: Do surface changes alter biological behaviour?

Plasma polymerized bioceramics for drug delivery: Do surface changes alter biological behaviour?

Thin film deposition at atmospheric pressure using dielectric barrier discharges: Advances on three-dimensional porous substrates and functional coatings

Multi-nanolayer drug delivery using radio frequency plasma technology

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