Love waves for (bio)-chemical sensing in liquids

Kovacs, Günter; Lubking, G.W.; Vellekoop, M.J.; Venema, A.

doi:10.1109/ultsym.1992.275995

Cited by 97 publications

(75 citation statements)

References 10 publications

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“…As far as the higher-order Love mode at 704 MHz is concerned, we have noticed that its gas sensitivity is orders of magnitude lower than the STW mode on the right side. This lack of sensitivity is explained by the fact that the Love mode scatters its energy into the bulk of the sensing layer [20]. Table 1 prior to (upper plots) and after (lower plots) 190 nm HMDSO solid film deposition…”

Section: Electrical Performance Of Stw/rsaw Sensor Resonators Coated mentioning

confidence: 99%

Polymer Coated Rayleigh SAW and STW Resonators for Gas Sensor Applications

Avramov¹

2011

Acoustic Waves - From Microdevices to Helioseismology

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Section: Electrical Performance Of Stw/rsaw Sensor Resonators Coated mentioning

confidence: 99%

Polymer Coated Rayleigh SAW and STW Resonators for Gas Sensor Applications

Avramov¹

2011

Acoustic Waves - From Microdevices to Helioseismology

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“…The surface potential ( ) 1 , 0 x φ must be the same on both sides of the boundary however the normal components of the electrical displacement can differ. The discontinuity is related to the potential by the effective permittivity ( )…”

Section: Boundary Conditionsmentioning

confidence: 99%

“…The transduction mechanism for Love wave sensors is based on propagating waves with a shearhorizontal polarization (SH) along the propagation direction. The SH polarization minimizes attenuation of the surface acoustic wave (SAW) into viscous media permitting detection in fluids [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Shear horizontal surface acoustic wave microsensor for Class A viral and bacterial detection.

Branch¹,

Huber²,

Brozik³

et al. 2008

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The rapid autonomous detection of pathogenic microorganisms and bioagents by field deployable platforms is critical to human health and safety. To achieve a high level of sensitivity for fluidic detection applications, we have developed a 330 MHz Love wave acoustic biosensor on 36° YX Lithium Tantalate (LTO). Each die has four delay-line detection channels, permitting simultaneous measurement of multiple analytes or for parallel detection of single analyte containing samples. Crucial to our biosensor was the development of a transducer that excites the shear horizontal (SH) mode, through optimization of the transducer, minimizing propagation losses and reducing undesirable modes. Detection was achieved by comparing the reference phase of an input signal to the phase shift from the biosensor using an integrated electronic multi-readout system connected to a laptop computer or PDA. The Love wave acoustic arrays were centered at 330 MHz, shifting to 325-328 MHz after application of the silicon dioxide waveguides. The insertion loss was −6 dB with an out-of-band rejection of 35 dB. The amplitude and phase ripple were 2.5 dB p-p and 2-3° p-p, respectively. Time-domain gating confirmed propagation of the SH mode while showing suppression of the triple transit. Antigen capture and mass detection experiments demonstrate 4 a sensitivity of 7.19 ± 0.74 ° mm 2 / ng with a detection limit of 6.7 ± 0.40 pg / mm 2 for each channel.5 CONTENTS

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“…frequency dependent) and exist provided that the shear velocity in the thin guiding layer is less than the shear velocity in the substrate. Love-wave devices have been used for both mass [3][4][5] and viscosity detection [1,6]. Although SH waves show no interaction with ideal liquids, there is interaction with viscous liquids.…”

Section: Introductionmentioning

confidence: 99%

Low-Level Detection of a Bacillus Anthracis Simulant using Love-Wave Biosensors on 36 Degree YX LiTaO3

Branch¹,

Brozik²

2003

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Crucial to low-level detection of biowarfare agents in aqueous environments is the mass sensitivity optimization of Love-wave acoustic sensors. The present work is an experimental study of 36°YX cut LiTaO 3 based Love-wave devices for detection of pathogenic spores in aqueous conditions. Given that the detection limit (DL) of Love-wave based sensors is a strong function of the overlying waveguide, two waveguide materials have been investigated, which are polyimide and polystyrene. To determine the mass sensitivity of Love-wave sensor, bovine serum albumin (BSA) protein was injected into the Love-wave test cell while recording magnitude and phase shift across each sensor. Polyimide had the lowest mass detection limit with an estimated value of 1-2 ng/cm 2 , as compared to polystyrene where DL = 2.0 ng/cm 2 .Suitable chemistries were used to orient antibodies on the Love-wave sensor using adsorbed protein G. The thickness of each biofilm was measured using ellipsometry from which the surface concentrations were calculated. The monoclonal antibody BD8 with a high degree of selectivity for anthrax spores was used to capture the non-pathogenic simulant B. thuringiensis B8 spores. Bacillus Subtilis spores were used as a negative control to determine whether significant non-specific binding would occur. Spore aliquots were prepared using an optical counting method, which permitted removal of background particles for consistent sample 4 preparation. This work demonstrates that Love-wave devices can be used to detect B. anthracis simulant below reported infectious levels.5

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Love waves for (bio)-chemical sensing in liquids

Cited by 97 publications

References 10 publications

Polymer Coated Rayleigh SAW and STW Resonators for Gas Sensor Applications

Polymer Coated Rayleigh SAW and STW Resonators for Gas Sensor Applications

Shear horizontal surface acoustic wave microsensor for Class A viral and bacterial detection.

Low-Level Detection of a Bacillus Anthracis Simulant using Love-Wave Biosensors on 36 Degree YX LiTaO3

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