“…The effect of S-acylation on trafficking and turnover rate is not only related to membrane partitioning but also to the interplay with ubiquitination ( Abrami et al, 2006 , 2008 ; Hach et al, 2013 ; Yount et al, 2012 ; Zaballa and van der Goot, 2018 ). S-acylation crosstalk with other modifications has been repeatedly reported ( Ahearn et al, 2011 ; Nepal et al, 2023 ; Wang et al, 2023b ; Yan et al, 2022 ), as recently reviewed ( Ramzan et al, 2023 ; Zmuda and Chamberlain, 2020 ). In the context of degradation, it occurs frequently with ubiquitination, which could be mono, multi, or polyubiquitination ( Dikic and Schulman, 2023 ).…”