Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer

The role of transcription factor Yin Yang‐1 in colorectal cancer

“…28,38,39,62,63 Whereas, controversial views are raised in terms of CRC treatment. 13,64,65 It yet reminds us that the influence of YY1 on the evolution process of CRC and different therapeutic regimens might be overlooked in the past. So far, there are sporadic clinical trials concerning YY1 as a prognostic predictor in breast cancer, follicular lymphoma, diffuse large B-cell lymphoma, endotoxemia, and pediatric sepsis 70,72,73,76 (Table 3).…”

“…It is worth noting that the existence of feedback loop engaging YY1 and ncRNAs amplifies their joint oncogenic action (Figure 2). 28,38,39,62,63 Whereas, controversial views are raised in terms of CRC treatment 13,64,65 . It yet reminds us that the influence of YY1 on the evolution process of CRC and different therapeutic regimens might be overlooked in the past.…”

“… 28 , 38 , 39 , 62 , 63 Whereas, controversial views are raised in terms of CRC treatment. 13 , 64 , 65 It yet reminds us that the influence of YY1 on the evolution process of CRC and different therapeutic regimens might be overlooked in the past.…”

“…Considering CRC, the majority of studies demonstrate the oncogenic role of YY1, while several incongruences are reported (Table 2). For instance, loss of YY1 was reported to be significantly associated with aggressive phenotypes and prognosis in CRC patients 13,64,65 . In research setting, YY1 plays a positive role of 5‐fluorouracil‐induced cytotoxicity in two CRC cell lines, HT‐29 and SW620.…”

“…For instance, loss of YY1 was reported to be significantly associated with aggressive phenotypes and prognosis in CRC patients. 13 , 64 , 65 In research setting, YY1 plays a positive role of 5‐fluorouracil‐induced cytotoxicity in two CRC cell lines, HT‐29 and SW620. Further investigation showed that YY1 modulates the apoptotic response of both cell lines by indirectly interacting with BCL2L15, a member of Bcl‐2 family of apoptotic gene regulators.…”