Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma
Mercy Akuma,
Minjun Kim,
Chenxuan Zhu
et al.
Abstract:The von Hippel-Lindau (VHL) tumor suppressor is a component of E3 ubiquitin ligase complexes that target cellular substrates for proteasome-mediated degradation. VHL inactivation by genetic aberrations is observed in most sporadic cases of clear cell renal cell carcinoma (ccRCC). VHL loss leads to constitutive stabilization of E3 ligase targets, including hypoxia inducible factor α (HIFα), in VHL-associated tumors. HIFα stabilization upon VHL loss promotes transactivation of hypoxia responsive genes, which con… Show more
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