Loss of TSS1 in hypervirulent Coxiella burnetii 175, the causative agent of Q fever in French Guiana

D'Amato, Felicetta; Eldin, Carole; Georgiades, Kalliopi; Edouard, Sophie; Delerce, Jérémy; Labas, N.; Raoult, Didier

doi:10.1016/j.cimid.2015.04.003

Cited by 29 publications

(28 citation statements)

References 40 publications

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“…Since 2003, six new whole genomes of C. burnetii have become available in GenBank (142)(143)(144). Sixteen incomplete genomes can also be found (27,47,(145)(146)(147)(148)(149)(150).…”

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

“…These features were consistent with genome reduction due to recent adaptation of C. burnetii to an intracellular lifestyle. More recently, D'Amato et al performed a pangenomic analysis of the seven sequenced strains of C. burnetii (144). The Dugway strain exhibited the largest genome (2,158,758-bp chromosome and 54,179-bp QpDG plasmid).…”

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

“…The core genome/pangenome ratio was 96%. A total of 13,542 core genes (shared by all strains), 498 accessory genes (found in some strains), and 88 unique genes (found in a single strain) were found (144). Seventy-four unique genes were found in the Dugway strain, 13 in the Q212 strain, and a single gene in the RSA331 strain.…”

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

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From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.

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“…Since 2003, six new whole genomes of C. burnetii have become available in GenBank (142)(143)(144). Sixteen incomplete genomes can also be found (27,47,(145)(146)(147)(148)(149)(150).…”

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

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From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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“…Celui-ci correspond à la région de l'opéron hlyCABD du système de sécrétion type I (T1SS). La virulence de cette souche pourrait donc être liée à une réduction gé-nomique (D'Amato et al 2015).…”

Section: Cycle Intracellulaire Et Facteurs De Virulenceunclassified

Coxiella burnetii, agent de la fièvre Q

Boarbi¹,

Frétin²,

Mori³

2016

Can. J. Microbiol.

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Résumé : La fièvre Q est une zoonose de répartition mondiale excepté la Nouvelle-Zélande. Elle est due à une bactérie intracellulaire : Coxiella burnetii. Cette infection passe souvent inaperçue car la manifestation principale de la forme aiguë de la maladie est un syndrome pseudogrippal spontanément résolutif. C'est l'épidémie qui a eu lieu aux Pays-Bas qui a attiré l'attention sur cette maladie qui était moins étudiée auparavant. Cette synthèse résume la description de la bactérie (taxonomie, cycle intracellulaire et génomique) mais également la maladie (description, diagnostic, pathogénie et épidémiologie). Enfin, la vaccination de l'humain et des animaux est également analysée. Mots-clés : Coxiella burnetii, fièvre Q, épidémiologie, description, génomique.Abstract: Q fever is a zoonosis of worldwide distribution with the exception of New Zealand. It is caused by an intracellular bacterium, Coxiella burnetii. The disease often goes underdiagnosed because the main manifestation of its acute form is a general self-limiting flu-like syndrome. The Dutch epidemics renewed attention to this disease, which was less considered before. This review summarizes the description of C. burnetii (taxonomy, intracellular cycle, and genome) and Q fever disease (description, diagnosis, epidemiology, and pathogenesis). Finally, vaccination in humans and animals is also considered.

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“…Comparative analysis of these genomes highlighted their diversity regarding pseudogene content and number of insertion sequence (IS) elements, possibly explaining their biological differences (Beare et al 2009). Recently, along with the development of powerful sequencing platforms, the numbers of sequenced genomes has blossomed to more than 40, 26 being publically available (D'Amato et al 2014, Karlsson et al 2014, Sidi-Boumedine et al 2014, Walter et al 2014, D'Amato et al 2015, Hammerl et al 2015. Despite the large number of genome records for C. burnetii since 2003, only 9 genomes are fully sequenced and annotated as closed circular genomes, the remainder are available as fragmented scaffolds, contigs or whole genome shot gun sequences in various genome databases (https://www.patricbrc.org/portal/portal/patric/Home, https://www.ncbi.nlm.nih.gov/genome/genomes/543).…”

Section: Genome and Genetic Chacterizationmentioning

confidence: 99%

Critical Aspects for Detection ofCoxiella burnetii

Mori

Mertens

Cutler

et al. 2017

Vector-Borne and Zoonotic Diseases

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Abstract:Coxiella burnetii is a global distributed zoonotic γ-proteobacterium with an obligatory intracellular lifestyle. It is the causative agent of Q fever in humans and of coxiellosis amongst ruminants, albeit the agent is also detected in ticks, birds and various other mammalian species. Requirements for intracellular multiplication together with the necessity for biosafety level 3 facilities restrict the cultivation of C. burnetii to specialized laboratories. Development of a novel media formulation enabling axenic growth of C. burnetii has facilitated fundamental genetic studies. This review provides critical insights into direct diagnostic methods currently available for C. burnetii. It encompasses molecular detection methods, isolation and propagation of the bacteria and its genetic characterization. Differentiation of C. burnetii from Coxiella-like organisms is an essential diagnostic prerequisite, particularly when handling and analyzing ticks.

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Loss of TSS1 in hypervirulent Coxiella burnetii 175, the causative agent of Q fever in French Guiana

Cited by 29 publications

References 40 publications

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

Coxiella burnetii, agent de la fièvre Q

Critical Aspects for Detection ofCoxiella burnetii

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