Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies
Sonja Fernbach,
Nina K. Mair,
Irene A. Abela
et al.
Abstract:Autoantibodies neutralizing type I interferons (IFN-Is) can underlie infection severity. Here, we trace the development of these autoantibodies at high-resolution using longitudinal samples from 1,876 well-treated individuals living with HIV over a 35-year period. Similar to general populations, ∼1.9% of individuals acquired anti-IFN-I autoantibodies as they aged (median onset ∼63 years). Once detected, anti-IFN-I autoantibodies persisted lifelong, and titers increased over decades. Individuals developed disti… Show more
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