Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study

Zalejska–Fiolka, Jolanta; Birková, Anna; Wielkoszyński, Tomasz; Hubková, Beáta; Szlachta, Beata; Fiolka, Rafał; Błaszczyk, Urszula; Kuzan, Aleksandra; Gamian, Andrzej; Mareková, Mária; Toborek, Michał

doi:10.3390/ijerph19021001

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…However, those patients who lost more than 5% of SMM had the highest glucose and fructosamine levels and HOMA-IR before the program. This indicates the influence of glycemic status on tissue loss and supports our previous results [27].…”

Section: Discussionsupporting

confidence: 93%

“…Previous findings indicate that reducing visceral fat is the most favorable metabolically, whereas reducing skeletal muscle or water is less favorable [26][27][28]. Our previous research also revealed that weight reduction through a balanced diet and exercise is more effective in normoglycemic compared to hyperglycemic women with obesity.…”

Section: Discussionmentioning

confidence: 64%

“…Our previous research also revealed that weight reduction through a balanced diet and exercise is more effective in normoglycemic compared to hyperglycemic women with obesity. However, weight loss in hyperglycemic individuals led to an undesired loss of non-fat tissues, such as skeletal muscle mass, body protein content, and intracellular and total body water [27].…”

Section: Discussionmentioning

confidence: 99%

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Serum Oxidative Status in People with Obesity: Relation to Tissue Losses, Glucose Levels, and Weight Reduction

Szlachta,

Birková,

Wielkoszyński

et al. 2023

Antioxidants

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Background: This work aims to study the effect of reductions in various body mass components on the oxidative, glycemic, and lipid parameters of people with obesity (PWO). Methods: A total of 53 PWO underwent a six-month individualized low-calorie diet combined with moderate exercise, during which anthropometric, biochemical, and oxidative parameters were measured. Probands were divided into groups based on weight, visceral fat area (VFA), total body water (TBW), and skeletal muscle mass (SMM) losses. Results: Weight reduction normalizes glycemia, but VFA reduction is less pronounced, while SMM and TBW reductions are more pronounced in patients with higher initial concentrations of glucose and fructosamine. Moreover, changes in oxidative parameters correlate with changes in glucose. Conclusions: Weight loss, regardless of the reduced tissue, decreases cardiovascular risk. We observed a significant change in almost all parameters related to the redox state. In general, parameters responsible for antioxidant action improved, and markers of oxidative damage decreased. Malondialdehyde, lipid peroxides, and total oxidative status levels can be considered biomarkers reflecting only the current severity of reactive oxygen species genesis processes. When considering the glycemic state, the results are not as clear due to the substantial differences between normoglycemic and hyperglycemic patients. Glycemic status is a factor playing a crucial role in weight reduction.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Serum Oxidative Status in People with Obesity: Relation to Tissue Losses, Glucose Levels, and Weight Reduction

Szlachta,

Birková,

Wielkoszyński

et al. 2023

Antioxidants

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A continuous muscle-sparing advantage of pylorus-preserving gastrectomy for older patients with cT1N0M0 gastric cancer in the middle third of the stomach

et al. 2022

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Study on the Impact of Combined Exercise and Various Dietary Approaches Based on Digital Technology on the Body Composition of Obese College Students (Preprint)

ChengYuan,

Zixin,

Jieping

et al. 2024

Preprint

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BACKGROUND Obesity has become a global health crisis, with projections indicating that by 2030, the number of overweight or obese individuals in China will surge to 790 million. Lifestyle interventions are a crucial component of weight loss programs, yet digital, personalized, and theory- and evidence-based lifestyle interventions remain limited. OBJECTIVE To investigate the impact of a combination of various dietary approaches and exercise, based on digital technology, on the body composition of obese college students. METHODS A total of 129 college students (age: 18.3 ± 0.7 years, weight: 89.9 ± 13.6 kg, BMI: 30.6 ± 3.3 kg/m²) were recruited from Jiangxi Normal University. An 8-week weight loss intervention was conducted on obese college students using a combination of exercise and various dietary approaches based on digital intervention. The exercise regimen included two days per week of one-hour resistance training and at least five times per week of sunlight running, with each run not less than 2 km. The dietary interventions consisted of a low-calorie diet (LCD), a twice-per week fasting diet (TWF), and a 16/8 time-restricted feeding diet (TRF). Changes in body composition indicators (muscle mass, fat mass, and water content) were assessed before and after the intervention. Participants were divided into three groups (LCD, TWF, TRF) for the experiment. RESULTS The 8-week intervention led to improvements in the body composition of obese college students. Additionally, it was found that compared to baseline, the male participants in the TWF group experienced a significant reduction in fat indices, and the female participants in the LCD group also showed a significant decrease in fat indices after the 8-week intervention. CONCLUSIONS In the process of weight loss through the combination of exercise and dieting, using digital technology methods, various dietary approaches combined with exercise have distinct effects on body composition. Among the muscle indices, the TRF group experienced a rapid decrease in lean body mass at four weeks, which remained stable at eight weeks, with a slight increase observed in females. Regarding fat indices, males in the TWF group achieved better fat reduction, while females in the LCD group had a more significant decrease in fat mass. In terms of water content, both males and females in the TWF group maintained better hydration levels. CLINICALTRIAL Chinese Clinical Trial Registry ChiCTR2300073166

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Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study

Cited by 4 publications

References 35 publications

Serum Oxidative Status in People with Obesity: Relation to Tissue Losses, Glucose Levels, and Weight Reduction

Serum Oxidative Status in People with Obesity: Relation to Tissue Losses, Glucose Levels, and Weight Reduction

A continuous muscle-sparing advantage of pylorus-preserving gastrectomy for older patients with cT1N0M0 gastric cancer in the middle third of the stomach

Study on the Impact of Combined Exercise and Various Dietary Approaches Based on Digital Technology on the Body Composition of Obese College Students (Preprint)

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