Loss of Skeletal Muscle Mass and Poor Prognosis in Patients with ST-Segment Elevation Myocardial Infarction: Underling Mechanisms and Therapeutic Strategies

Shimada, Kazunori

doi:10.5551/jat.ed135

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Sarcopenia is a progressive and generalized skeletal muscle disorder involving the accelerated loss of muscle mass and function that is associated with increased adverse outcomes including falls, functional decline, frailty, and mortality [31]. Several reports have shown that sarcopenia has a poor prognosis in cases of cardiovascular diseases such as heart failure and AMI [32][33][34]. Kanda et al reported that AMI patients with malnutrition on admission are more likely to progress to sarcopenia [35].…”

Section: Discussionmentioning

confidence: 99%

Cut-off values of geriatric nutritional risk index for cardiovascular events in acute myocardial infarction patients

Ito

Inoue

Nagoshi

et al. 2023

Preprint

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Low Geriatric Nutritional Risk Index (GNRI) in patients with heart failure is associated with poor prognosis. However, the usefulness of GNRI for patients with acute myocardial infarction (AMI) remains controversial. We evaluated the optimal cut-off values of GNRI for cardiovascular events in AMI patients by time-dependent receiver operating characteristic (ROC) analysis to examine its usefulness. We retrospectively investigated the optimal cut-off values for two endpoints of all-cause death and major adverse cardiac events (MACE: all-cause death, non-fatal myocardial infarction, hospitalization for heart failure, stroke) over 48 months in 360 patients with AMI who required emergency admission to our hospital between January 2012 and February 2020. The cumulative incidence of MACE over 48 months was 11.6%. The cut-off value of GNRI for all-cause death was 82.7 (AUC 0.834) at 3 months, 89.3 (AUC 0.861) at 12 months, and 90.3 (AUC 0.854) at 48 months. The cut-off value of GNRI for MACE was 83.0 (AUC 0.841) at 3 months, 95.7 (AUC 0.863) at 12 months, and 95.3 (AUC 0.821) at 48 months. Time-dependent ROC analysis showed that the optimal cut-off value of GNRI varied over time. The optimal cut-off value of GNRI is a useful predictor for prognosis in patients with AMI.

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Section: Discussionmentioning

confidence: 99%

Cut-off values of geriatric nutritional risk index for cardiovascular events in acute myocardial infarction patients

Ito

Inoue

Nagoshi

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…On the other hand, the presence of sarcopenia is also associated with cardiorespiratory diseases and adversely affects the cardiovascular system, causing endothelial and vascular dysfunction. Erkan et al found that sarcopenia was an independent risk factor for higher major adverse cardiovascular events in elderly patients with NSTEMI, and other studies also showed poor outcomes in this patient profile [56][57][58]. Moreover, a relationship between poor handgrip strength, slowing walking pace, and CAD has been observed [59,60].…”

Section: Sarcopeniamentioning

confidence: 97%

The Impact of Geriatric Conditions in Elderly Patients with Coronary Heart Disease: A State-of-the-Art Review

Alonso Salinas,

Cepas-Guillén,

León

et al. 2024

JCM

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The growing geriatric population presenting with coronary artery disease poses a primary challenge for healthcare services. This is a highly heterogeneous population, often underrepresented in studies and clinical trials, with distinctive characteristics that render them particularly vulnerable to standard management/approaches. In this review, we aim to summarize the available evidence on the treatment of acute coronary syndrome in the elderly. Additionally, we contextualize frailty, comorbidity, sarcopenia, and cognitive impairment, common in these patients, within the realm of coronary artery disease, proposing strategies for each case that may assist in therapeutic approaches.

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Loss of Skeletal Muscle Mass and Poor Prognosis in Patients with ST-Segment Elevation Myocardial Infarction: Underling Mechanisms and Therapeutic Strategies

Cited by 2 publications

References 17 publications

Cut-off values of geriatric nutritional risk index for cardiovascular events in acute myocardial infarction patients

Cut-off values of geriatric nutritional risk index for cardiovascular events in acute myocardial infarction patients

The Impact of Geriatric Conditions in Elderly Patients with Coronary Heart Disease: A State-of-the-Art Review

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