“…13 More depression and poorer psychosocial adjustment by DM patients with DFU compared to those without has been shown in early 14 and recent 15 studies. In general, adverse psychological effects associated with DFU include a sense of loss of self, social isolation, 16 loss of self-esteem, fear, anger, helplessness, and depression. 11,13,17 Patients may worry about the ulcer itself, the potential for new ulcers to develop, and the possibility of amputation.…”