Loss of NAT10 alleviates maternal high‐fat diet‐induced hepatic steatosis in male offspring of mice
Qian‐Ren Zhang,
Jian‐Bin Zhang,
Feng Shen
et al.
Abstract:ObjectiveMetabolic dysfunction‐associated steatotic liver disease (MASLD) is becoming an escalating health problem in pediatric populations. This study aimed to investigate the role of N‐acetyltransferase 10 (NAT10) in maternal high‐fat diet (HFD)‐induced MASLD in offspring at early life.MethodsWe generated male hepatocyte‐specific NAT10 knockout (Nat10HKO) mice and mated them with female Nat10fl/fl mice under chow or HFD feeding. Body weight, liver histopathology, and expression of lipid metabolism–associated… Show more
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