Loss of red cell mass in a plasmapheresis machine: Effect of rinsing the disposable tubing with normal saline and reinfusion

Fischer, Thorsten; Surikova, Irina; Heesen, Ewa; Wilms, Galina; Laitinen, Teija; Taborski, Uwe

doi:10.1016/j.transci.2013.05.031

Cited by 8 publications

(15 citation statements)

References 6 publications

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“…GDM = Gestational diabetes mellitus; IGT = Impaired glucose tolerance.Data are given as means ± SD or number (%).Effect sizes from regression models: Continuous variables as estimated marginal mean difference (95% CIs) and categorized variables as odds ratios (95% CIs).a) Unadjusted analysis; b) Linear or generalized linear mixed model adjusted for cluster (random factor), age and prepregnancy BMI.c) In 221 (Control n = 74, Intervention n = 147) women a standardized 2 h oral glucose tolerance test was performed; GDM or IGT was defined according to the clinical practice guidelines of the German Society of Gynecology and Obstetrics from 2010 [69]. …”

Section: Resultsmentioning

confidence: 99%

“…In addition, each counseling session included an individual component where women received personalized feedback on their nutrition and physical activity habits based on 7-day-dietary records and physical activity questionnaires. In the diet component, we explained general topics like energy balance and a healthy nutrition according to the “Deutsche Gesellschaft für Ernährung” (DGE) (German Nutrition Society) [65]. We informed participants about additional energy requirements as well as macro- and micronutrient requirements during pregnancy.…”

Section: Methodsmentioning

confidence: 99%

“…The control group received routine prenatal care including an information leaflet with ten general statements about a healthy lifestyle during pregnancy [68], but no advice on diet or gaining weight.…”

Section: Methodsmentioning

confidence: 99%

“…All participants were offered a free standardized two hour oral glucose tolerance test (OGTT) between the 24 th and 28 th week of gestation, to screen for gestational diabetes mellitus (GDM). Tests were performed and interpreted according to the 2010 clinical practice guidelines of the German Society of Gynecology and Obstetrics [69]. A follow-up interview (phone call or e-mail) was arranged four months pp for both groups to record self-reported maternal weights for monitoring of weight retention.…”

Section: Methodsmentioning

confidence: 99%

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Safety and efficacy of a lifestyle intervention for pregnant women to prevent excessive maternal weight gain: a cluster-randomized controlled trial

Rauh

Gabriel

Kerschbaum

et al. 2013

BMC Pregnancy Childbirth

122

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BackgroundExcessive gestational weight gain (GWG) is associated with short- and long-term health problems among mothers and their offspring. There is a strong need for effective intervention strategies targeting excessive GWG to prevent adverse outcomes.MethodsWe performed a cluster-randomized controlled intervention trial in eight gynecological practices evaluating the feasibility and effectiveness of a lifestyle intervention presented to all pregnant women; 250 healthy, pregnant women were recruited for the study. The intervention program consisted of two individually delivered counseling sessions focusing on diet, physical activity, and weight monitoring. The primary outcome was the proportion of pregnant women exceeding weight gain recommendations of the Institute of Medicine (IOM). Secondary outcome variables were maternal weight retention and short-term obstetric and neonatal outcomes.ResultsThe intervention resulted in a lower proportion of women exceeding IOM guidelines among women in the intervention group (38%) compared with the control group (60%) (odds ratio (OR): 0.5; 95% confidence interval (CI): 0.3 to 0.9) without prompting an increase in the proportion of pregnancies with suboptimal weight gain (19% vs. 21%). Participants in the intervention group gained significantly less weight than those in the control group. Only 17% of the women in the intervention group showed substantial weight retention of more than 5 kg compared with 31% of those in the control group at month four postpartum (pp) (OR: 0.5; 95% CI: 0.2 to 0.9). There were no significant differences in obstetric and neonatal outcomes.ConclusionsLifestyle counseling given to pregnant women reduced the proportion of pregnancies with excessive GWG without increasing suboptimal weight gain, and may exert favorable effects on pp weight retention.Trial registrationGerman Clinical Trials Register DRKS00003801.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Safety and efficacy of a lifestyle intervention for pregnant women to prevent excessive maternal weight gain: a cluster-randomized controlled trial

Rauh

Gabriel

Kerschbaum

et al. 2013

BMC Pregnancy Childbirth

122

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“…If saline infusion was given after PP the loss of red cell mass with the tubing system could be reduced from 12,0 ml to 1,3 ml per donation on average [5]. However, the disadvantage of this method is that hypovolemic events cannot be prevented during PP.…”

mentioning

confidence: 99%

Unexpected Hypotensive Events during Preparatory Plasmaphereses

Evers¹

2014

Transfus Med Hemother

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Impact of saline infusion and citrate infusion rate during donor plasmapheresis

Evers

Schreiber

Taborski

2022

J of Clinical Apheresis

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The purpose of our research was to evaluate the effects of saline infusion to counteract incidents of severe hypotension during donor plasmapheresis (DP; synonym with plasma donation), and on immunoglobulin G (IgG) content in collected plasma, and on donor hematological values. It examines the clearance (Cl) of IgG during DP without saline to calculate the distribution of citrate and citrate infusion rate (CIR) during DP. It is based on three studies: an observation of saline infusion in donors with severe drops in blood pressure at DP, and two crossover trials of 32 repeat plasma donors each on saline infusion during DP. We observed 50 cases with a significant drop of mean systolic blood pressure ≤90 mm Hg in 1 year, predominantly in young, female first‐time donors. In trial 1, there was a reduction of IgG concentration in collected plasma related to the average IgG serum concentration without saline to 85.5% vs to 80.5% with saline (P < .001). In trial 2, there was an important 11%‐12% increase of the donor hematological values without saline during DP. An average of 84.6% of citrate was removed in retained plasma; our calculated minimal CIR of 0.16 ± 0.17 mg/kg/min was confirmed by other empirical studies. Our research has led to significant improvements in the practice of DP: (a) Saline should be infused at DP as clinically indicated in agreement with the donor. (b) Young, female first‐time donors require special care. (c) The long‐time effects of minimal amounts of citrate on bone metabolism are improbable.

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Loss of red cell mass in a plasmapheresis machine: Effect of rinsing the disposable tubing with normal saline and reinfusion

Cited by 8 publications

References 6 publications

Safety and efficacy of a lifestyle intervention for pregnant women to prevent excessive maternal weight gain: a cluster-randomized controlled trial

Safety and efficacy of a lifestyle intervention for pregnant women to prevent excessive maternal weight gain: a cluster-randomized controlled trial

Unexpected Hypotensive Events during Preparatory Plasmaphereses

Impact of saline infusion and citrate infusion rate during donor plasmapheresis

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