Loss of quality of life associated with genital warts: baseline analyses from a prospective study

Sénécal, Martin; Brisson, Marc; Maunsell, Elizabeth; Ferenczy, Alex; Franco, Eduardo L.; Ratnam, Sam; Coutlée, François; Palefsky, Joel M.; Mansi, James A.

doi:10.1136/sti.2009.039982

Cited by 31 publications

(30 citation statements)

References 27 publications

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“…It is particularly notable that the impact of GW on psychosocial burden appears to be greater than that of diseases such as VIN2/3, which are considered to be more severe from a clinical perspective and have been shown to have a significant impact on sexual functioning in previous studies [30,45]. The high psychosocial impact of GW may be because they are visible and distressing and associated with discomfort and feelings of anxiety, depression, anger, fear of contagiousness, shame and embarrassment [22,23,25,46]. In addition, treatment of GW is long, painful and often unsatisfactory, with high recurrence rates [3].…”

Section: Discussionmentioning

confidence: 99%

Impact of human papillomavirus-related genital diseases on quality of life and psychosocial wellbeing: results of an observational, health-related quality of life study in the UK

et al. 2013

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BackgroundData on the psychosocial burden of human papillomavirus (HPV)-related diseases other than cervical cancer are scarce. The objectives of this study were to measure and compare the psychosocial burden and the impact on health-related quality of life (HRQoL) of HPV-related lower genital tract diseases and genital warts (GW) using several generic and disease-specific instruments.MethodsOverall, 842 individuals with normal cervical cytology (n = 241), borderline nuclear abnormalities and/or mild dyskaryosis (n = 23), cervical intraepithelial neoplasia (CIN)1 (n = 84), CIN2/3 (n = 203), vulval intraepithelial neoplasia (VIN)2/3 (n = 43), GW (n = 186) and a history of GW (non-current) (n = 62) were included. The generic European Quality of Life Index Version 5D (EQ-5D) questionnaire was completed by patients with GW and VIN2/3. Sexual functioning was evaluated using the Change in Sexual Functioning Questionnaire (CSFQ). Psychosocial impact was measured in women using the HPV Impact Profile (HIP) questionnaire. HRQoL was assessed using a GW-specific questionnaire, the Cuestionario Especifico en Condilomas Acuminados (CECA) (completed by patients with GW and history of GW). For each instrument, scores were compared between groups using the Student's t-test. In addition, utility loss due to GW and VIN2/3 was evaluated by comparing mean EQ-5D scores weighted by age and sex with the UK general population normal values.ResultsA significant psychosocial impact was found in women diagnosed with HPV-related genital diseases, particularly in those with GW. The health state of younger adults with GW was significantly impaired compared with UK normal values (mean EQ-5D index score 0.86 vs 0.94, p < 0.001 for 18–24-year-olds; 0.87 vs 0.93, p = 0.030 for 25–34-year-olds). VIN2/3 was found to have a significant negative impact on sexual functioning, and women with VIN2/3 had a highly impaired health state compared with women in the UK general population (weighted mean EQ-5D index score 0.72 vs 0.89, p < 0.001; weighted mean Visual Analogue Scale score 62 vs 85, p < 0.001).ConclusionsHPV-related lower genital tract lesions and GW significantly impair psychosocial wellbeing and HRQoL. The psychosocial aspects of HPV-related diseases need to be considered when evaluating the potential benefit of HPV vaccination.

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Section: Discussionmentioning

confidence: 99%

Impact of human papillomavirus-related genital diseases on quality of life and psychosocial wellbeing: results of an observational, health-related quality of life study in the UK

et al. 2013

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“…Globally, genital warts are estimated to affect approximately 1% of the human population [5], although the incidence in sexually transmitted disease clinics is approximately 13% [6]. Although genital warts are benign, they may cause discomfort and affect psychological well-being because they are often untreated [7-9]. …”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus in Thai Women and Men with Anogenital Warts

et al. 2018

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Objective: Anogenital warts are caused by human papillomavirus (HPV). Globally, HPV genotypes 6 and 11 are most often associated with anogenital warts. However, the diversity of HPV genotypes found in patients with genital warts in Thailand is unknown. The aim of this study was to investigate HPV-associated anogenital warts in the Thai population and to assess whether genotypes found are represented in the bivalent and quadrivalent HPV vaccine. Methods: This study included 206 anogenital swab samples from patients who were diagnosed with anogenital warts. Detection of HPV DNA was performed using polymerase chain reaction to amplify the L1 gene and sequencing. Results: HPV was identified in 88.3% (182/206) of the samples. The majority of HPV genotypes were low-risk genotypes HPV6 (36.9%) and HPV11 (36.4%), which represented the most common infection found in genital warts in this study. Conclusion: Immunization with the quadrivalent vaccine (HPV6, HPV11, HPV16, and HPV18) could potentially prevent genital warts caused by HPV infection.

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“…Tüm bu faktörlerden yola çıkarak genital siğilin yaşam kalitesi üzerine olumsuz etkileri öngörülmüş, bu hastalarda yaşam kalitesini araştıran çalışmalar yapılmıştır. Çeşitli merkezlerde yapılan çalışmaların tamamında genital siğilin yaşam kalitesi üzerine olumsuz etkileri gösterilmiştir [1][2][3][4][5][6][7][8][9] . Bu konuda ülkemizde yapılmış bir çalışma mevcut değildir.…”

Section: Introductionunclassified

Evaluation of the quality of life in patients with genital warts

Erdem¹,

Özarmağan²

2016

TURKDERM

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Background and Design: Genital warts, a very common sexually-transmitted infection, negatively affect the quality of life of patients especially from the psychosocial point of view. In this study, we aimed to investigate the effects of genital warts on the quality of life by comparing patient and control groups. Materials and Methods: Eighty patients and 75 healthy individuals were included in the study. The 36-item Short-form health survey and Dermatology life quality index (DLQI) were administered to patients whereas the control group was given only the SF-36. The obtained data were evaluated together with the clinical and demographical data by comparing the patient and control groups. Results: According to the sub-dimensions of the SF-36, a significant effect was observed in the patient group compared to the control group for the general health, vitality and mental health. The average DLQI score was 5.14±4.13. In all sub-dimensions of SF-36, the scores in female patients were found to be statistically significantly lower than in male patients. No significant correlation was determined between clinical characteristics and quality of life. Conclusion: Genital warts are a disease which negatively affects the quality of life and results in psychosocial problems and changes in sexual activity.

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Loss of quality of life associated with genital warts: baseline analyses from a prospective study

Abstract: The results suggest that genital warts negatively affect the wellbeing of men and women as reflected by poorer quality of life scores compared with population norms.

Cited by 31 publications

References 27 publications

Impact of human papillomavirus-related genital diseases on quality of life and psychosocial wellbeing: results of an observational, health-related quality of life study in the UK

Impact of human papillomavirus-related genital diseases on quality of life and psychosocial wellbeing: results of an observational, health-related quality of life study in the UK

Human Papillomavirus in Thai Women and Men with Anogenital Warts

Evaluation of the quality of life in patients with genital warts

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