2010
DOI: 10.1158/0008-5472.can-09-4291
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Loss of Osteoclasts Contributes to Development of Osteosarcoma Pulmonary Metastases

Abstract: We conducted a transcriptomic screen of osteosarcoma (OS) biopsies and found that expression of osteoclast-specific tartrate-resistant acid phosphatase 5 (ACP5/TRAP) is significantly downregulated in OS compared with nonmalignant bone (P < 0.0001). Moreover, lesions from OS patients with pulmonary metastases had 2-fold less ACP5/TRAP expression (P < 0.018) than lesions from patients without metastases. In addition, we found a direct correlation (P = 0.0166) between ACP5/TRAP expression and time to metastasis. … Show more

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Cited by 74 publications
(76 citation statements)
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References 56 publications
(49 reference statements)
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“…For microarray analysis, complementary RNA was generated with the Illumina TotalPrep RNA Amplification Kit and hybridized with Illumina HumanHT-12 v4 Expression BeadChips (Illumina) as per the manufacturer's protocol. Expression data from the microarrays were analyzed as previously described (25). The microarray data reported in this article have been deposited in the NCBI's Gene Expression Omnibus (GEO) database under the accession number GSE58074.…”
Section: Gene-expression Studiesmentioning
confidence: 99%
“…For microarray analysis, complementary RNA was generated with the Illumina TotalPrep RNA Amplification Kit and hybridized with Illumina HumanHT-12 v4 Expression BeadChips (Illumina) as per the manufacturer's protocol. Expression data from the microarrays were analyzed as previously described (25). The microarray data reported in this article have been deposited in the NCBI's Gene Expression Omnibus (GEO) database under the accession number GSE58074.…”
Section: Gene-expression Studiesmentioning
confidence: 99%
“…OPG is a potent apoptosis inhibitor of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on tumor cells. The loss of osteoclasts in the primary tumors enhances the OS metastases (Endo-Munoz et al, 2010a). The decrease of osteoclasts is consistent with a decreased antigen-presenting activity, an enhanced chemoresistance and an impaired osteoclastogenesis (Endo-Munoz et al, 2010b).…”
Section: Deregulation Of Bone Destruction Mechanisms and Cells (Osteomentioning
confidence: 59%
“…Metastatic potential of a tumor is primarily dependent on the migratory ability of the cells (25,26).…”
Section: Discussionmentioning
confidence: 99%