Loss of Oligodendrocytes by Oxidative Phosphorylation Inhibitor Rotenone and its Reversal by Phenylbutyrate (PB) in Human Brain Developmental Organoid Model

Abstract

During development, the Neuro-Epithelial Cells (NECs) give rise to the primary stem-cells (NSC), the apical radial glia (aRG) [4]. As the brain develops, aRGs will become confined to the primary cortical germinal layer, known as the ventricu-