Loss of oestrogen receptor β, high PCNA and p53 expression and aneuploidy as markers of worse prognosis in ovarian granulosa cell tumours

Staibano, Stefania; Franco, Renato; Mezza, E.; Chieffi, Paolo; Sinisi, Antonio Agostino; Pasquali, Daniela; Errico, Maria Elena; Nappi, C.; Tremolaterra, F.; Somma, Pasquale; Mansueto, Gelsomina; Rosa, Gaetano De

doi:10.1046/j.1365-2559.2003.01706.x

Cited by 42 publications

(34 citation statements)

References 46 publications

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“…First, the down-regulation of ER, observed in seminomas, was in accordance with our previously published data, and from animal models and human cell culture studies suggesting that ER may control cell proliferation during germ cells cancer progression [7,8,[21][22][23][24] . These considerations induce to hypothesize that…”

Section: Gpr30 Is a Potential Therapeutic Targetsupporting

confidence: 87%

GPR30 is a Potential Therapeutic Target in Human Carcinoma in situ and Seminomas

Chieffi

2015

Receptor Clin Invest

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The G protein-coupled estrogen receptor (GPR30) is suggested to exert a role in non-nuclear estrogen signalling and is over-expressed in a variety of hormone dependent cancer entities. It is well established that oestrogens are involved in testicular germ cell tumours. In a recent paper published in Journal of Cellular Physiology, we show that down regulation of estrogen receptor β (ERβ) associates with GPR30 over-expression both in human testicular carcinoma in situ (CIS) and seminomas. In addition, we demonstrate that 17-oestradiol induces the ERK1/2 activation through GPR30. The results suggested that exposure to oestrogens or oestrogen-mimics, in some as of yet undefined manner, diminishes the ER-mediated growth restraint in CIS and in human testicular seminoma, indicating that GPR30 could be a potential therapeutic target to design specific inhibitors.

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Section: Gpr30 Is a Potential Therapeutic Targetsupporting

confidence: 87%

GPR30 is a Potential Therapeutic Target in Human Carcinoma in situ and Seminomas

Chieffi

2015

Receptor Clin Invest

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“…well-differentiated carcinomas and overall, the Aurora B overexpression group demonstrated a significantly shorter progression-free survival and survival than a low expression group (16). In human colorectal cancer samples the correlation of Aurora B expression with overall survival was also evaluated, showing that patients with a high expression level of Aurora B lived significantly shorter lives compared with patients with low expression levels .…”

Section: Aurora B and Cancermentioning

confidence: 97%

“…The inhibition of Aurora B kinase has an antiproliferative effect and causes regression in several animal models of human cancers, including breast, colon, lung, leukemia, prostate and thyroid (15)(16)(17)(18)(19)(20)(21)(22). These observations strongly suggest a potential role for Aurora B inhibition in patients.…”

Section: Aurora B As Therapeutic Targetmentioning

confidence: 98%

“…Aurora B is overexpressed in several human cancers, such as non small cell lung carcinoma (8), mesothelioma (9), glioblastoma (7) oral cancer (10), malignant endometrium, hepatocellular carcinoma (11), testicular germ cell tumours (12)(13)(14)(15), ovarian (16,17), thyroid (18,19), colon (20) and prostate (21,22). Aurora B expression is positively correlated with poor prognosis and displays a tendency to group in higher grades of malignancy in different neoplastic lesions.…”

Section: Aurora B and Cancermentioning

confidence: 99%

“…Aurora B expression is positively correlated with poor prognosis and displays a tendency to group in higher grades of malignancy in different neoplastic lesions. Aurora B expression directly correlates with Gleason grade in prostate cancer (21,22), Duke's grade in colorectal cancer (20) and dedifferentiation in ovary and thyroid carcinoma (16,18). In thyroid tumours, an increase of Aurora B expression has been observed in papillary and anaplastic thyroid carcinomas.…”

Section: Aurora B and Cancermentioning

confidence: 99%

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Aurora B: A new promising therapeutic target in cancer

Chieffi¹

2018

IRDR

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The high‐mobility group A1‐estrogen receptor β nuclear interaction is impaired in human testicular seminomas

Esposito¹,

Boscia²,

Gigantino³

et al. 2012

Journal Cellular Physiology

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It is well established that estrogens participate in the control of normal spermatogenesis and endogenous or environmental estrogens are involved in pathological germ cell proliferation including testicular germ cell tumors. The effects of estrogen are now known to be mediated by estrogen receptor-α (ERα) and ERβ subtypes, but only ERβ has been found in human germ cells of normal testis. However, its expression was markedly diminished in human testicular seminomas. The expression and the possible interaction of ERβ and HMGA1 were studied in normal germ cells and in human testicular seminomas. GC1 and TCam-2 germ cell lines, were used; in addition, a tissue micro-array (TMA) was built using the most representative areas from 35 cases of human testicular seminomas. The expression and the interaction of ERβ and HMGA1 were observed by using immunoprecipitation and Western blot analyses in combination with immunocytochemistry and immunofluorescence analyses. Here, we show that ERβ interacts with HMGA1 in normal germ cells, while down regulation of ERβ associates with transcriptional co-regulator HMGA1 over-expression and cytoplasmic localization both in human testicular seminomas and in TCam-2 cell line. In addition, we show that 17β-oestradiol induces an HMGA1 increased cytoplasmic expression associated to an ERβ down-regulation in TCam-2 cell line. Taken together, our results suggest that exposure to estrogens or estrogen-mimics, in some as of yet undefined manner, diminishes the ERβ-mediated growth restraint in human testicular seminoma, probably due to the HMGA1 cytoplasmic delocalization associated with ERβ down-regulation.

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Loss of oestrogen receptor β, high PCNA and p53 expression and aneuploidy as markers of worse prognosis in ovarian granulosa cell tumours

Cited by 42 publications

References 46 publications

GPR30 is a Potential Therapeutic Target in Human Carcinoma in situ and Seminomas

GPR30 is a Potential Therapeutic Target in Human Carcinoma in situ and Seminomas

Aurora B: A new promising therapeutic target in cancer

The high‐mobility group A1‐estrogen receptor β nuclear interaction is impaired in human testicular seminomas

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