Abstract:NR5A1 is an orphan nuclear receptor crucial for gonadal development in mammals. In the mouse testis it is expressed both in Sertoli cells (SC) and Leydig cells (LC). To investigate its role posteriorly to sex determination, we have generated and analysed mice lacking NR5A1 in SC from embryonic day (E) 13.5 onwards (Nr5a1 SC-/- mutants). Ablation of Nr5a1 impairs the expression of genes characteristic of SC identity (e.g., Sox9, Amh), makes SC to progressively die from E14.5 by a Trp53-independent mechanism, an… Show more
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