Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With <sup>123</sup>I‐FP‐CIT SPECT

Bae, Yun Jung; Kim, Jong Min; Kim, Eun‐Hee; Lee, Kyung Mi; Kang, Seo Young; Park, Hyun Soo; Kim, Kyeong Joon; Kim, Young Eun; Oh, Eung Seok; Yun, Ji Young; Kim, Jinhyun; Jeong, Hye Jin; Jeon, Beomseok; Kim, Sang Eun

doi:10.1002/mds.26584

Cited by 94 publications

(124 citation statements)

References 27 publications

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“…) . Subsequent studies using 3T MRI have also been able to replicate this finding in most PD patients (refer to Table for list of studies) . This replication has generated considerable interest to use nigrosome imaging as a way of studying and diagnosing nigral pathology in PD.…”

Section: Nigrosome Imagingmentioning

confidence: 80%

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Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

Pavese

Tai

2018

Movement Disord Clin Pract

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Background Recent developments in magnetic resonance imaging (MRI) techniques have offered new research opportunities to visualize in vivo substantia nigra pathology in Parkinson's disease (PD). This paper summarizes the main findings of nigrosome imaging and neuromelanin sensitive MRI studies in patients with PD and other parkinsonisms. Methods The PubMed database was searched from 2005 to 2017 using the following keywords: Parkinson's disease and parkinsonism, in combination with MRI, nigrosome, neuromelanin, and iron. Only publications in English were included. Results Nigrosome or dorsal nigral hyperintensity abnormalities are studied using T2* and susceptibility weighted imaging MRI sequences in most studies, whereas Neuromelanin imaging is usually performed using T1‐weighted fast spin echo sequence. Nigrosome abnormalities have been consistently demonstrated in PD patients, and nigrosome imaging has high sensitivity and specificity in distinguishing PD from healthy controls, though it is unable to reliably separate PD from atypical parkinsonisms. Reduced neuromelanin‐related signals and/or volume loss in neuromelanin containing structures have been found in PD patients, and neuromelanin sensitive MRI imaging can also discriminate PD patients from healthy controls with high accuracy, though there is a degree of heterogeneity in the imaging findings. Preliminary findings suggested that longitudinal change of neuromelanin signal could be detected in PD, raising the possibility of using it as a marker of disease progression. Conclusion Nigrosome imaging and neuromelanin sensitive MRI are promising tools to study nigral pathology and to improve the diagnosis of PD. However, further studies are required to standardize analysis approaches, confirm longitudinal changes, and assess their generalizability.

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Section: Nigrosome Imagingmentioning

confidence: 80%

“…The nigrosome abnormality also correlates with nigrostriatal dopaminergic dysfunction as detected by DAT SPECT. The absence of dorsolateral nigral hyperintensity in PD subjects predicted ipsilateral striatal DAT signal abnormality with a sensitivity of 87.5% (95% CI, 83.5%–90.7%) and specificity of 83.6% (95% CI, 77.6%–88.2%) …”

Section: Nigrosome Imagingmentioning

confidence: 99%

Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

Pavese

Tai

2018

Movement Disord Clin Pract

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“…The 3 studies each included subjects with APDs or subjects with parkinsonism and normal dopaminergic radiotracer imaging . Data on these subjects with non‐PD parkinsonism were not included in the meta‐analysis because of an insufficient number of studies (≥4 studies needed for the meta‐analysis as described later), but analyzed descriptively.…”

Section: Methodsmentioning

confidence: 99%

“…Most patients with PD or other types of neurodegenerative parkinsonism studied so far lack DNH at least unilaterally (see Fig. A) . Although current evidence thus suggests that this novel MRI feature may be a marker for PD, available studies have mostly involved small samples and had heterogeneous control populations.…”

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confidence: 99%

Meta‐analysis of dorsolateral nigral hyperintensity on magnetic resonance imaging as a marker for Parkinson's disease

et al. 2017

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“…However, because the absence of this finding also was observed in all patients with PSP and in 83 of 90 patients with PD, its clinical usefulness in differentiating between different causes of neurodegenerative parkinsonism is questionable, although it seems to be specific for neurodegenerative parkinsonism . Another recent study also showed that the loss of dorsolateral nigral hyperintensity is observed in patients with neurodegenerative parkinsonism, including MSA; furthermore, it corresponds to presynaptic dopaminergic imaging with a concordance rate of 86.2% …”

Section: Mri Findings Of Msamentioning

confidence: 98%

Role of Magnetic Resonance Imaging in the Diagnosis of Multiple System Atrophy

Kim

Jeon

Fung

2016

Movement Disord Clin Pract

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Background: Multiple system atrophy (MSA) is a rapidly progressing neurodegenerative disorder without effective disease-modifying therapies. Because of a lack of reliable diagnostic biomarkers, there has been increasing interest in using magnetic resonance imaging (MRI) to improve the diagnostic accuracy of MSA.Methods: This review summarizes recent literatures on the role of MRI in the diagnosis of MSA. Results: Several MRI abnormalities on conventional MRI already are included in the current diagnostic criteria for MSA. Other features on conventional MRI are also used to make a diagnosis of MSA or to rule out alternative diagnoses. On the other hand, some of the MRI findings that were previously considered suggestive of a diagnosis of MSA are now being challenged, because it turned out that they were not as specific to MSA as previously thought. More advanced MRI modalities, including susceptibility-weighted imaging, diffusion-weighted imaging, diffusion tensor imaging, voxel-based morphometry, and cortical thickness analysis, are now used to study the changes in the brains of patients with MSA. Furthermore, studies have produced promising results demonstrating the use of MRI as a tool for monitoring and assessing disease progression in MSA. Conclusions: MRI is useful and indispensable in the diagnosis of MSA and also possibly for monitoring disease progression. In this regard, well-designed, long-term, prospective studies on large numbers of patients are needed.

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Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With ¹²³I‐FP‐CIT SPECT

Cited by 94 publications

References 27 publications

Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

Meta‐analysis of dorsolateral nigral hyperintensity on magnetic resonance imaging as a marker for Parkinson's disease

Role of Magnetic Resonance Imaging in the Diagnosis of Multiple System Atrophy

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Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With 123I‐FP‐CIT SPECT

Cited by 94 publications

References 27 publications

Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

Meta‐analysis of dorsolateral nigral hyperintensity on magnetic resonance imaging as a marker for Parkinson's disease

Role of Magnetic Resonance Imaging in the Diagnosis of Multiple System Atrophy

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Product

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Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With ¹²³I‐FP‐CIT SPECT