Loss of methylation imprint of Snrpn in postovulatory aging mouse oocyte

Liang, Xingwei; Zhu, Jiaqiao; Miao, Yi‐Liang; Liu, Jinghe; Liang, Wei; Lu, Sen; Hou, Yi; Schatten, Heide; Ke-huan, LU; Sun, Qing‐Yuan

doi:10.1016/j.bbrc.2008.03.105

Cited by 61 publications

(60 citation statements)

References 38 publications

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“…Previous observations by others and us have shown that postovulatory oocyte aging not only results in aberrant DNA methylation patterns of imprinted genes in oocytes during the process of oocyte aging (12,13) but that it also has adverse effects on methylation and expression of H19 in placentas at the midgestation developmental stage (14). These findings suggest that postovulatory oocyte aging has deleterious effects on genomic imprinting.…”

mentioning

confidence: 70%

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Effect of postovulatory oocyte aging on DNA methylation imprinting acquisition in offspring oocytes

Liang

Guo

et al. 2011

Fertility and Sterility

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mentioning

confidence: 70%

“…PCR reactions were carried out according to our previous reports with slight modifications (12,17). Briefly, nested PCR was performed using one bead containing bisulfite-treated DNA in the first-round PCR and 2 mL of the first-round PCR products as a template in the second-round PCR.…”

Section: Pcr Amplificationmentioning

confidence: 99%

Effect of postovulatory oocyte aging on DNA methylation imprinting acquisition in offspring oocytes

Liang

Guo

et al. 2011

Fertility and Sterility

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“…Both the male and female genomes experience significant demethylation events following fertilization (Mayer et al 2000) and post-ovulatory oocyte ageing has been shown to significantly alter the methylation pattern of imprinted genes in both the oocyte and the developing placenta (Liang et al 2008(Liang et al , 2011.…”

Section: Abnormalities In Offspringmentioning

confidence: 99%

“…Post-ovulatory aged oocytes exhibit numerous aberrations in their cell biology including partial cortical granule exocytosis (Szollosi 1971, Dodson et al 1989, Ducibella et al 1990, Xu et al 1997, zona hardening (Longo 1981, Dodson et al 1989, Xu et al 1997, a decrease in critical cell cycle factors including maturation-promoting factor (MPF) and MAPK (Kikuchi et al 2002), mitochondrial dysfunction (Chi et al 1988, Takahashi et al 2003, Tatone et al 2011, Zhang et al 2011, Lord et al 2013, spindle abnormalities (Wakayama et al 2004), losses of chromosomal integrity (Spielmann et al 1985, Mailhes et al 1998, Wakayama et al 2004) and epigenetic changes (Liang et al 2008; Table 1). Not surprisingly, the process of post-ovulatory ageing culminates in apoptosis (Fujino et al 1996) as a result of decreases in expression of the anti-apoptotic protein BCL2 (Gordo et al 2002, Ma et al 2005) and the activation of caspases (Takai et al 2007, Lord et al 2013.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and ageing of the post-ovulatory oocyte

2013

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With extended periods of time following ovulation, the metaphase II stage oocyte experiences deterioration in quality referred to as post-ovulatory oocyte ageing. Post-ovulatory ageing occurs both in vivo and in vitro and has been associated with reduced fertilization rates, poor embryo quality, post-implantation errors and abnormalities in the offspring. Although the physiological consequences of post-ovulatory oocyte ageing have largely been established, the molecular mechanisms controlling this process are not well defined. This review analyses the relationships between biochemical changes exhibited by the ageing oocyte and the symptoms associated with the ageing phenotype. We also discuss molecular events that are potentially involved in orchestrating post-ovulatory ageing with a particular focus on the role of oxidative stress. We propose that oxidative stress may act as the initiator for a cascade of events that create the aged oocyte phenotype. Specifically, oxidative stress has the capacity to cause a decline in levels of critical cell cycle factors such as maturation-promoting factor, impair calcium homoeostasis, induce mitochondrial dysfunction and directly damage multiple intracellular components of the oocyte such as lipids, proteins and DNA. Finally, this review addresses current strategies for delaying post-ovulatory oocyte ageing with a particular focus on the potential use of compounds such as caffeine or selected antioxidants in the development of more refined media for the preservation of oocyte integrity during IVF procedures.

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“…These methylation patterns in gametes must be maintained during early development after fertilization. We previously examined methylation patterns of imprinted genes in mouse oocytes during the postovulatory aging process [45]. In our study, methylation of two maternally imprinted genes, Snrpn and Peg1, were examined in in vivo and in vitro oocytes at 13, 21 and 29 h post hCG injection, respectively.…”

Section: Dna Methylationmentioning

confidence: 99%

Epigenetic changes associated with oocyte aging

Liang

Schatten

et al. 2012

Sci. China Life Sci.

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It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age. Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process. Here, we review the epigenetic alterations, mainly focused on DNA methylation, histone acetylation and methylation associated with postovulatory oocyte aging as well as advanced maternal age. Furthermore, we address the underlying epigenetic mechanisms that contribute to the decline in oocyte quality during oocyte aging.

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Loss of methylation imprint of Snrpn in postovulatory aging mouse oocyte

Cited by 61 publications

References 38 publications

Effect of postovulatory oocyte aging on DNA methylation imprinting acquisition in offspring oocytes

Effect of postovulatory oocyte aging on DNA methylation imprinting acquisition in offspring oocytes

Oxidative stress and ageing of the post-ovulatory oocyte

Epigenetic changes associated with oocyte aging

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