Loss of long‐term benefit from VIM‐DBS in essential tremor: A secondary analysis of repeated measurements

Abstract

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Which one is the superior target? A comparison and pooled analysis between posterior subthalamic area and ventral intermediate nucleus deep brain stimulation for essential tremor

“…Regarding long‐term efficacy, PSA and VIM stimulation both significantly decreased with longer follow‐up periods. This may be due to the increased tolerance of patients to stimulation, and the progressing process of ET 31,64 . Disease progression was also recognized as an important reason for the loss of efficacy 65 .…”

“…This may be due to the increased tolerance of patients to stimulation, and the progressing process of ET. 31 , 64 Disease progression was also recognized as an important reason for the loss of efficacy. 65 Anthofer et al reported that patients with long distant contact with DRTT fibers were more prone to suffer from DBS tolerance.…”