Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site

Ulaner, Gary A.; Vu, Thanh H.; Li, Tao; Hu, Ji Fan; Yao, Xiao Ming; Yang, Youwen; Görlick, Richard; Meyers, Paul A.; Healey, John H.; Ladanyi, Marc; Hoffman, Andrew R.

doi:10.1093/hmg/ddg034

Cited by 133 publications

(65 citation statements)

References 40 publications

(58 reference statements)

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“…21 This has been extensively studied in neoplastic disorders, including bone tumors. 22,23 However, little is known about the potential role of DNA methylation in normal bone and non-neoplastic bone disorders.…”

Section: Discussionmentioning

confidence: 99%

Role of DNA methylation in the regulation of the RANKL-OPG system in human bone

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Role of DNA methylation in the regulation of the RANKL-OPG system in human bone

et al. 2012

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“…H19 and the adjacent protein-coding gene IGF2 are imprinted in most normal tissues, and this imprinting is often lost in tumors (Ulaner et al 2003a, Ulaner et al 2003b). This loss of imprinting is associated with differential methylation of a CTCF-binding site upstream of H19.…”

Section: Osteogenesis and Osteosarcomamentioning

confidence: 99%

Could lncRNAs be the Missing Links in Control of Mesenchymal Stem Cell Differentiation?

Tye

Gordon

Martin-Buley

et al. 2014

Journal Cellular Physiology

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Long suspected, recently recognized, and increasingly studied, non protein-coding RNAs (ncRNAs) are emerging as key drivers of biological control and pathology. Since their discovery in 1993, microRNAs (miRNAs) have been the subject of intense research focus and investigations have revealed striking findings, establishing that these molecules can exert multiples levels of biological control in numerous tissues. More recently, long ncRNAs (lncRNAs), the lesser-studied siblings of miRNA, have been suggested to have a similar robust role in developmental and adult tissue regulation. Mesenchymal stem cells (MSCs) are an important source of multipotent cells for normal and therapeutic tissue repair. Much is known about the critical role of miRNAs in biogenesis and differentiation of MSCs however; recent studies have suggested lncRNAs may play an equally important role in the regulation of these cells. Here we highlight the role of lncRNAs in the regulation of mesenchymal stem cell lineages including adipocytes, chondrocytes, myoblasts and osteoblasts. In addition, the potential for these noncoding RNAs to be used as biomarkers for disease or therapeutic targets is also discussed.

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“…Loss of imprinting (LOI) in paternal allele and the resulting overexpression of H19 was found in various cancers including lung cancer [67], oesophagus cancer [68], osteosarcoma [69], and bladder cancer [70]. H19 upregulation was found related to a range of risk factors such as smoking, carcinogens exposuring, and hypoxia.…”

Section: H19mentioning

confidence: 99%

Long Non-Coding RNA in Non-Small Cell Lung Cancers

Cheng¹,

Mao²

2017

A Global Scientific Vision - Prevention, Diagnosis, and Treatment of Lung Cancer

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Non-small cell lung cancer (NSCLC) accounts for nearly 80% of diagnosed lung cancers. Due to the predominantly late diagnosis of NSCLC and drug resistance in the targeted therapy approaches, the 5-year overall survival rate is still less than 19%. Thus, novel diagnosis and treatment approaches are needed. Many eforts have been made to achieve great progress in understanding the genomic landscape of NSCLC and the molecular mechanisms involved in tumorigenesis. Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides with litle or no protein-coding potential.They are encoded across the genome and are involved in a wide range of cellular and biological processes. Dysregulation of lncRNAs is associated with a number of cancerrelated processes, including epigenetic regulation, microRNA silencing, and DNA damage. Furthermore, lncRNAs have been reported to have the potential as biomarker for diagnosis and prognosis, as well as the therapy targets. Here in this chapter, we review some well-characterized lncRNAs associated with NSCLCs and the potential of lncRNAs as biomarkers in the diagnosis and prognosis of NSCLCs.

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Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site

Cited by 133 publications

References 40 publications

Role of DNA methylation in the regulation of the RANKL-OPG system in human bone

Role of DNA methylation in the regulation of the RANKL-OPG system in human bone

Could lncRNAs be the Missing Links in Control of Mesenchymal Stem Cell Differentiation?

Long Non-Coding RNA in Non-Small Cell Lung Cancers

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