Loss of IL17 signaling in lupus-prone Ets1 knockout mice leads to worsened autoimmunity combined with increased susceptibility to Staphylococcal skin infections
Abstract:Ets1 is a lineage-specific transcription factor that regulates B and T cell functions in development and disease. Mice that lack Ets1 (Ets1 KO) develop autoimmune disease with high levels of autoantibodies. Naïve CD4+ T cells isolated from Ets1 KO mice differentiate more readily to IL17 producing Th17 cells. To determine if IL17 production contributes to the observed autoimmunity in Ets1 KO mice, we crossed Ets1 KO mice to mice lacking the IL17 receptor A subunit (IL17RA KO) to generate double knock out (DKO) … Show more
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