Loss of heterozygosity of Kras2 gene on 12p12-13 in Chinese colon carcinoma patients

Wan, Jun; Li, Hong; Li, Yuan; Zhu, Meiling; Zhao, Po

doi:10.3748/wjg.v12.i7.1033

WJG

2006

DOI: 10.3748/wjg.v12.i7.1033

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Loss of heterozygosity of Kras2 gene on 12p12-13 in Chinese colon carcinoma patients

Jun Wan¹,

Hong Li²,

Yuan Li³

et al.

Abstract: AIM:To study the loss of heterozygosity (LOH) on 12p12-13 in Chinese colon carcinoma patients.

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Cited by 2 publications

References 29 publications

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Loss of heterozygosity in oral cancer

Kasamatsu

Uzawa

Usukura

et al. 2011

Oral Science International

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a b s t r a c tThe development and progression of oral squamous cell carcinoma (OSCC) is a multistep process, which involves many genetic factors. Among them, loss of heterozygosity (LOH) studies have been used to identify regions on chromosomes that may contain putative tumor suppressor genes (TSGs). Here, we searched PubMed for relevant publications including our previous studies and compared results of LOH in OSCCs from the articles. LOHs in OSCCs were observed at various loci on almost all chromosomes, except X and Y. In this review, the LOH in patients with OSCC and the interrelationship between TSGs and OSCC initiation and progression are discussed.

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Loss of heterozygosity in oral cancer

Kasamatsu

Uzawa

Usukura

et al. 2011

Oral Science International

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Epigenetic Mechanisms in Cancer

Banerjee

Verma

2009

Biomarkers Med.

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After the completion of the human genome, a need was identified by scientists to look for a functional map of the human genome. Epigenomics provided functional characteristics of genes identified in the genome. Epigenetics is the alteration in gene expression (function) without changing the nucleotide sequence. Both activation and inactivation of cancer-associated genes can occur by epigenetic mechanisms. The major players in epigenetic mechanisms of gene regulation are DNA methylation, histone deacetylation, chromatin remodeling, small noncoding RNA expression and gene imprinting. In the last few years, epigenetic mechanisms have been studied in a number of tumor types and epigenetic markers have been identified that are suitable for cancer detection, diagnosis, follow-up of treatment and screening high-risk populations. One interesting aspect of epigenetics is the reactivation of genes by successful reversion of some epigenetic changes using chemicals. The reversibility of epigenetic aberrations has made them attractive targets for cancer treatment with modulators that demethylate DNA and inhibit histone deacetylases, leading to the reactivation of silenced genes. In this article, we have described the current status of this powerful science and discussed the challenges in the clinical fields where epigenetic approaches in cancer are applied.

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Loss of heterozygosity of Kras2 gene on 12p12-13 in Chinese colon carcinoma patients

Abstract: AIM:To study the loss of heterozygosity (LOH) on 12p12-13 in Chinese colon carcinoma patients.

Cited by 2 publications

References 29 publications

Loss of heterozygosity in oral cancer

Loss of heterozygosity in oral cancer

Epigenetic Mechanisms in Cancer

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