Abstract:Background
Management of platelet‐transfusion refractory (PR) patients due to anti‐HLA antibodies includes the provision of HLA‐matched (HLAm) platelets (PLT) or PLTs that are negative for HLA antigens corresponding to the recipient antibodies. Obtaining HLAm PLTs is predicated on accurate HLA antigen typing of the recipient and donor. Here, we present the clinical implications of a case involving loss of heterozygosity (LOH) in a patient presented for PR workup.
Study Design and Methods
HLA typing was perform… Show more
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