Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification.

Fong, Chin‐To; Dracopoli, Nicholas C.; White, Peter S.; Merrill, Pauline T.; Griffith, Rogers C.; Housman, David E.; Brodeur, Garrett M.

doi:10.1073/pnas.86.10.3753

Cited by 332 publications

(188 citation statements)

References 51 publications

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“…This gene encodes the beta subunit of the barbed-end actin binding protein that regulates growth of the actin filament by capping the barbed end of growing actin filaments. Those investigators mapped the CAPZB gene to 1p36.1, which has frequent loss of heterozygosity observed in neuroblastomas (Fong et al, 1989) and in oropharyngeal epithelial carcinomas (Grati et al, 2000). Jullien-Flores et al (1995) obtained a cDNA encoding RALBP1, which they termed RLIP76.…”

Section: Discussionmentioning

confidence: 99%

Aberrant expression of RAB1A in human tongue cancer

et al. 2005

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This study was designed to identify specific gene expression changes in tongue squamous cell carcinomas (TSCCs) compared with normal tissues using in-house cDNA microarray that comprised of 2304 full-length cDNAs from a cDNA library prepared from normal oral tissues, primary oral cancers, and oral cancer cell lines. The genes identified by our microarray system were further analysed at the mRNA or protein expression level in a series of clinical samples by real-time quantitative reverse transcriptasepolymerase chain reaction (qRT -PCR) analysis and imuunohositochemistry. The microarray analysis identified a total of 16 genes that were significantly upregulated in common among four TSCC specimens. Consistent with the results of the microarray, increased mRNA levels of selected genes with known molecular functions were found in the four TSCCs. Among genes identified, Rab1a, a member of the Ras oncogene family, was further analysed for its protein expression in 54 TSCCs and 13 premalignant lesions. We found a high prevalence of Rab1A-overexpression not only in TSCCs (98%) but also in premalignant lesions (93%). Thus, our results suggest that rapid characterisation of the target gene(s) for TSCCs can be accomplished using our in-house cDNA microarray analysis combined with the qRT -PCR and immunohistochemistry, and that the Rab1A is a potential biomarker of tongue carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Aberrant expression of RAB1A in human tongue cancer

et al. 2005

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“…Losses of 1p have been correlated with advanced stages and poor prognosis in some studies 3,21,54,57 and larger losses are associated with MYCN amplification. 14,15,52,58 Other investigators however have not identified an association between LOH and MYCN amplification 21 or prognosis. 58 For local-regional tumors and stage 4S, the data are less clear, although some groups have correlated 1p LOH with poor prognosis in low-risk groups.…”

Section: Discussionmentioning

confidence: 99%

“…14,15,52,58 Other investigators however have not identified an association between LOH and MYCN amplification 21 or prognosis. 58 For local-regional tumors and stage 4S, the data are less clear, although some groups have correlated 1p LOH with poor prognosis in low-risk groups. 2 In the present study composed of cases consistently treated at a single institution, LOH of 1p36 and 1p22 was associated with stage and MYCN amplification and LOH of 1p36 was associated with survival (See Tables 1 and 3).…”

Section: Discussionmentioning

confidence: 99%

Clinical Categories of Neuroblastoma Are Associated with Different Patterns of Loss of Heterozygosity on Chromosome Arm 1p

Mora

Cheung

Kushner

et al. 2000

The Journal of Molecular Diagnostics

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“…These tumors account for 15% of childhood cancer deaths and are particularly noted for a wide range in clinical behavior, ranging from spontaneous regression to rapid progression and death owing to disease (Brodeur, 2003). Loss of chromosome 1p material, occurring predominately through an unbalanced t(1;17) that also results in gain of 17q (Van Roy et al, 1994), is a common chromosomal imbalance found in NB and occurs preferentially in tumors with MYCN amplification (MNA) (Fong et al, 1989). All three of these nonrandom genetic abnormalities, loss of 1p, gain of 17q and MNA, are independently associated with a poor clinical outcome (Brodeur et al, 1984;Spitz et al, 2003;Attiyeh et al, 2005;Vandesompele et al, 2005).…”

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confidence: 99%

MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

2007

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Neuroblastoma (NB) is one of the most common forms of cancer in children, accounting for 15% of pediatric cancer deaths. The clinical course of these tumors is highly variable and is dependent on such factors as age at presentation, stage, ploidy and genomic abnormalities. Hemizygous deletion of chromosome 1p occurs in approximately 30% of advanced stage tumors, is associated with a poor prognosis, and likely leads to the loss of one or more tumor suppressor genes. We show here that microRNA (miRNA)-34a (1p36.23) is generally expressed at lower levels in unfavorable primary NB tumors and cell lines relative to normal adrenal tissue and that reintroduction of this miRNA into three different NB cell lines causes a dramatic reduction in cell proliferation through the induction of a caspase-dependent apoptotic pathway. As a potential mechanistic explanation for this observation, we demonstrate that miR-34a directly targets the messenger ribonucleic acid (mRNA) encoding E2F3 and significantly reduces the levels of E2F3 protein, a potent transcriptional inducer of cell-cycle progression. Furthermore, miR-34a expression increases during retinoic acidinduced differentiation of the SK-N-BE cell line, whereas E2F3 protein levels decrease. Thus, adding to the increasing role of miRNAs in cancer, miR-34a may act as a suppressor of NB tumorgenesis.

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Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification.

Cited by 332 publications

References 51 publications

Aberrant expression of RAB1A in human tongue cancer

Aberrant expression of RAB1A in human tongue cancer

Clinical Categories of Neuroblastoma Are Associated with Different Patterns of Loss of Heterozygosity on Chromosome Arm 1p

MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

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