“…In malignancies a loss of heterozygosity (LOH) of genomic sequences which accompanies the inactivation of tumour suppressor genes have been noted, and this is thought to be involved in a multistep accumulation of gene alterations crucial to leukaemogenesis (Rabbitts, 1994;Cline, 1994;Yokota & Sugimura, 1993). Loss of the short arm of chromosome 3 has been noted in many solid and haematological malignancies, most notably small cell lung carcinoma (SCLC) (Naylor et al, 1987;Brauch et al, 1990), non-small-cell lung carcinoma Miura et al, 1990), renal cell carcinoma Kovacs et al, 1988;Kovacs & Kung, 1991), breast carcinoma (Ali et al, 1989;Devilee et al, 1989), cervical carcinoma (Yokota et al, 1989) and chronic myeloid leukaemia (Tanaka et al, 1992). The putative tumour suppressor genes are thought to be most probably located in the 3p11-p21 region , the 3p21-p25 region and the 3p25 region (Seizinger et al, 1988).…”