Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function
Melissa J. Mann,
Chris Melendez-Suchi,
Hannah E. Vorndran
et al.
Abstract:GRP170 ( Hyou1) is required for mouse embryonic development, and its ablation in kidney nephrons leads to renal failure. Unlike most chaperones, GRP170 is the lone member of its chaperone family in the ER lumen. However, the cellular requirement for GRP170, which both binds non-native proteins and acts as nucleotide exchange factor for BiP, is poorly understood. Here, we report on the isolation of mouse embryonic fibroblasts obtained from mice in which LoxP sites were engineered in the Hyou1 loci ( Hyou1LoxP/L… Show more
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