Loss of glucocorticoid rhythm induces an osteoporotic phenotype in mice

Winter, Elizabeth M.; Schilperoort, Maaike; Kroon, Jan; Kooijman, Sander; Mletzko, Kathrin; Busse, Björn; Pereira, Alberto M.; Appelman-Dijkstra, NM; Bravenboer, Nathalie; Rensen, P.; Meijer, Onno C.

doi:10.1530/endoabs.70.oc2.4

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Chronotherapy Of Osteoporosis1

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2021

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“…( 136 ) It was long thought that negative effects of GCs on bone are solely attributable to supraphysiological GC levels resulting from GC treatment, but we have recently shown that a disturbed GC rhythm could also contribute substantially. ( 137 ) This finding is in line with the pivotal role of GC rhythm in mediating healthy bone remodeling, as discussed above, and emphasizes the importance of timing of GC therapy to limit its adverse effects.…”

Section: Chronotherapy Of Osteoporosissupporting

confidence: 77%

Chronobiology and Chronotherapy of Osteoporosis

et al. 2021

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Physiological circadian (ie, 24-hour) rhythms are critical for bone health. Animal studies have shown that genes involved in the intrinsic molecular clock demonstrate potent circadian expression patterns in bone and that genetic disruption of these clock genes results in a disturbed bone structure and quality. More importantly, circulating markers of bone remodeling show diurnal variation in mice as well as humans, and circadian disruption by, eg, working night shifts is associated with the bone remodeling disorder osteoporosis. In this review, we provide an overview of the current literature on rhythmic bone remodeling and its underlying mechanisms and identify critical knowledge gaps. In addition, we discuss novel (chrono)therapeutic strategies to reduce osteoporosis by utilizing our knowledge on circadian regulation of bone.

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Section: Chronotherapy Of Osteoporosissupporting

confidence: 77%