2006
DOI: 10.1016/j.jaci.2006.05.004
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Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations

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Cited by 548 publications
(452 citation statements)
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References 35 publications
(36 reference statements)
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“…A number of studies have been conducted to replicate the original findings, and some have confirmed and others refuted the association of FLG with AD (Marenholz et al 2006;Ruether et al 2006;Weidinger et al 2006Weidinger et al , 2007Barker et al 2007;Morar et al 2007;Stemmler et al 2007). To examine the association of common FLG variants with AD development, we performed tSNP analysis of Japanese AD families and case-control subjects.…”
Section: Discussionmentioning
confidence: 98%
See 1 more Smart Citation
“…A number of studies have been conducted to replicate the original findings, and some have confirmed and others refuted the association of FLG with AD (Marenholz et al 2006;Ruether et al 2006;Weidinger et al 2006Weidinger et al , 2007Barker et al 2007;Morar et al 2007;Stemmler et al 2007). To examine the association of common FLG variants with AD development, we performed tSNP analysis of Japanese AD families and case-control subjects.…”
Section: Discussionmentioning
confidence: 98%
“…FLG null alleles were also found to be associated with elevated levels of immunoglobulin E (IgE) (Weidinger et al 2006(Weidinger et al , 2007 and allergic sensitization (Weidinger et al 2006), and Marenholz et al (Marenholz et al 2006) reported that those mutations predispose carriers to asthma, allergic rhinitis, and allergic sensitization only in the presence of AD. Other FLG null mutations have also been found to be associated with AD in a Caucasian population ).…”
Section: Introductionmentioning
confidence: 99%
“…(41)(42)(43)(44) Genetic associations of FLG mutations with AD were confirmed and further verified by many independent groups using numerous cohorts of different populations e.g. American, (45) Caucasian and Northern-American AD, (2) European and Asian ancestry, (43,(46)(47)(48)(49)(50)(51) Chinese, (52) German, (53) Irish, (43) and Japanese. (54) More than 40 FLG loss-of-function mutations have been described in Europeans and Asians.…”
Section: -Filaggrin Genementioning
confidence: 67%
“…35 Other studies demonstrated that these mutations result in an extrinsic AD in patients suggesting that the skin barrier defect precedes the development of allergic sensitization in AD. 157 Since FLG mutations have not been commonly described in other non European populations, studies have analyzed mutations in other ancestral groups to determine the contribution of FLG mutations to AD pathogenesis worldwide. 158 In this regard, two novel FLG mutations reported in Japanese IV patients have recently been associated with AD.…”
Section: Epidermal Differentiation Complexmentioning
confidence: 99%