Loss-of-function cancer-associated mutations in the EIF4G2 non-canonical translation initiation factor
Sara Meril,
Marcela Bahlsen,
Miriam Eisenstein
et al.
Abstract:Tumor cells often exploit the protein translation machinery, resulting in enhanced protein expression essential for tumor growth. Since canonical translation initiation is often suppressed due to cell stress in the tumor microenvironment, non-canonical translation initiation mechanisms become particularly important for shaping the tumor proteome. EIF4G2 is a non-canonical translation initiation factor that mediates internal ribosome entry site [IRES] and upstream open reading frame [uORF] dependent initiation … Show more
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