Loss of frontal regulator of vigilance during sleep inertia: A simultaneous <scp>EEG‐fMRI</scp> study

Chen, Xinyuan; Hsu, Ching-Fen; Xu, Dan; Yu, Jing; Lei, Xu

doi:10.1002/hbm.25125

Cited by 18 publications

(13 citation statements)

References 48 publications

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“…The change of somnolence between the pretest and posttest was greater in the stimulation group, reflecting that 5Hz-tACS made subjects feel very sleepy. Except for this, the scales and behavioral measures in this study could not demonstrate a positive effect of electrical stimulation, but could corroborate the existence a sleep inertia [31]. In addition, almost all people reported that the eyes were closed at the same time as the stimulation, the eyes were stimulated, and the retina felt the effect of light flashing.…”

Section: Discussioncontrasting

confidence: 54%

Low Frequency Transcranial Alternating Current Stimulation Accelerates Sleep Onset Process

Xie¹,

Wang²,

Xiao³

et al. 2021

IEEE Trans. Neural Syst. Rehabil. Eng.

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The aim of this study is to find a kind of low frequency oscillation transcranial alternating current stimulation, which is directly applied to the scalp epidermal, to stimulate the cerebral cortex with a large spatial range of electric field oscillation across the brain hemisphere, and then trigger the start of the Top-Down processing of sleep homeostasis, in the daytime nap. Methods: Thirty healthy subjects, to take naps, underwent an intervention of electrical stimulation at 5 Hz, applied to the dorsal lateral prefrontal cortex. The subjects in the experiments were strictly controlled, and opened their eyes when stimulation was transmitted. Subsequently, after 15 min transcranial alternating current stimulation, subjects entered the experimental procedure of sleep. Electroencephalograph was taken at baseline and during sleep. Behavioral indicators were also added to the experiment. Results: We found that the total power of Electroencephalograph activity in the theta band, as well as low-frequency power at 1-7 Hz, was significantly entrained and increased, and that alpha activity was attenuated faster and spindle activity active earlier. Even more, the transition from awake to Non-rapid eye movement stages occurs earlier. Alertness also decreased when the subjects woke up after brief sleep. Conclusion: The intervention of low frequency brain rhythmic transcranial alternating current stimulation may induce accelerated effect on sleep onset process, thereby possibly alleviating the problems related to sleep disorders such as difficulty to reach the real sleep state quickly after lying down.

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Section: Discussioncontrasting

confidence: 54%

Low Frequency Transcranial Alternating Current Stimulation Accelerates Sleep Onset Process

Xie¹,

Wang²,

Xiao³

et al. 2021

IEEE Trans. Neural Syst. Rehabil. Eng.

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“…Additionally, a decrease in anticorrelation between the default-mode network (DMN) and task-positive networks (including the dorsal-attention, salience, and somatosensory networks) was observed after awakening from an afternoon nap (Vallat et al, 2019). In an EEG-fMRI fusion study, reduced correlation between the frontal-parietal network and EEG-vigilance was found during sleep inertia, although EEG-vigilance did not differ between pre-sleep and awakening (Chen et al, 2020). Overall, these ndings provide evidence that sleep inertia is a unique brain state characterized by altered functional network reorganizations and electrophysiology vigilance indices.…”

Section: Introductionmentioning

confidence: 98%

Dynamic Neurovascular Coupling during Sleep Inertia: An EEG-fMRI Fusion on Post-sleep Arousal and Spectral Slope

Wang

Lee

Chuang

et al. 2023

Preprint

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Upon emergence from sleep, individuals experience temporary hypo-vigilance and grogginess known as sleep inertia. During the transient period of vigilance recovery from prior nocturnal sleep, the neurovascular coupling (NVC) may not static and constant as assumed by previous neuroimaging studies. Stemming from this viewpoint in sleep inertia, this study aims to probe the NVC changes dynamically as awakening time prolongs using simultaneous EEG-fMRI. The time-lagged coupling between EEG features of vigilance and BOLD-fMRI signals, in selected regions of interest, was calculated with one pre-sleep and three consecutive post-awakening resting-state measures. We found marginal changes in EEG theta/beta ratio and spectral slope across post-awakening sessions, demonstrating alterations of vigilance during sleep inertia. Dynamic NVC as awakening prolonged was evidenced by the changing time lags of the peak correlation between EEG-vigilance and BOLD-thalamus, as well as BOLD-anterior cingulate cortex (ACC) and EEG spectral slope. This study provides the first evidence of potential dynamicity of NVC in sleep inertia and opens new avenues for non-invasive neuroimaging investigations into the neurophysiological mechanisms underlying brain state transitions.

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“…Considering that the actigraph actually measures motor activity, we propose that this measure can be a very useful behavioral index also for evaluating the phenomenon of SI. Indeed, it has been shown that ending sleep in the morning involves a reorganization of brain networks after awakening, including motor areas [17,18]. In particular, the default-mode network (DMN) showed a prompt recovery (within 6 min) after morning awakening, while the full reorganization of the connectivity of the Sensorimotor Network (SMN) was recovered within 30 min [19].…”

Section: Introductionmentioning

confidence: 99%

Time Course of Motor Sleep Inertia Dissipation According to Age

et al. 2022

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Sleep inertia (SI) refers to a complex psychophysiological phenomenon observed after morning awakening that can be described as the gradual recovery of waking-like status after a night of sleep. The time course of SI dissipation in an everyday life condition is little studied. The present study aims to investigate the SI dissipation in motor activity, as a function of age, upon spontaneous morning awakening after a usual night-time sleep. To this end, we performed a retrospective study in a naturalistic setting in a wide life span sample: 382 healthy participants (219 females) from middle childhood (9 years old) to late adulthood (70 years old). Participants were required to wear the actigraph on the non-dominant wrist for at least seven consecutive nights. Results show that SI of motor activity is dissipated in 70 min. Mean motor activity in such a time window was significantly modulated by age: lower age corresponded to higher motor activity.

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Loss of frontal regulator of vigilance during sleep inertia: A simultaneous EEG‐fMRI study

Cited by 18 publications

References 48 publications

Low Frequency Transcranial Alternating Current Stimulation Accelerates Sleep Onset Process

Low Frequency Transcranial Alternating Current Stimulation Accelerates Sleep Onset Process

Dynamic Neurovascular Coupling during Sleep Inertia: An EEG-fMRI Fusion on Post-sleep Arousal and Spectral Slope

Time Course of Motor Sleep Inertia Dissipation According to Age

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