Loss of efferent vagal activity in acute schizophrenia

Bär, Karl‐Jürgen; LETZSCH, A; Jochum, Thomas; Wagner, Gerd; GREINER, W; Sauer, Heinrich

doi:10.1016/j.jpsychires.2004.12.007

Cited by 160 publications

(113 citation statements)

References 38 publications

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“…[1][2][3]10,14 In contrast to previous studies, about half of the patients received antipsychotic medication, which possibly affects cardiac autonomic modulation, thus limiting the interpretation of data. However, we recently have demonstrated that olanzapine only exhibits minimal effects on the pattern of cardiovascular regulation in schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9] In particular, a disease-associated decrease in vagal modulation causes reduced heart rate variability (HRV) and diminished baro-reflex sensitivity (BRS). 2 HRV describes the continuous interplay between sympathetic and parasympathetic modulation of heart rate that reflects information on autonomic flexibility and responsiveness.…”

Section: Introductionmentioning

confidence: 99%

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Autonomic Dysfunction in Unaffected First-Degree Relatives of Patients Suffering From Schizophrenia

Bär

Berger

Metzner

et al. 2010

Schizophrenia Research

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Recent studies revealed cardiac autonomic dysfunction in patients with acute schizophrenia, which appears to be mainly related to reduced vagal and increased sympathetic modulation. To understand the significance of cardiac autonomic function in patients with schizophrenia, we extended these studies to relatives of patients. In this study, we assessed cardiac autonomic modulation in healthy first-degree relatives of patients with schizophrenia (n 5 36) to investigate a putative genetic influence. Data were compared with control subjects matched for age, gender, and physical activity as well as to patients suffering from schizophrenia. First-degree relatives showed an attenuated, yet identical pattern in autonomic dysfunction as patients with decreased vagal modulation of heart rate, decreased baroreflex sensitivity, but no difference in blood pressure variability could be detected. The patients' relatives also showed a similar pattern in regards to QT variability. In addition, the subgroup comparison of offspring vs. siblingsshowedasignificantdifferenceinheartratevariability suggesting a higher degree of heritability in offspring. In conclusion, the pattern of autonomic dysfunction seen in patients and relatives might indicate underlying disease-inherent genetic vulnerability, especially because autonomic parameters are heritable. In addition, these findings may be of value to identify the high-risk group of patients' relatives in regards to serious cardiovascular events so that early preventive measures can be taken.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Autonomic Dysfunction in Unaffected First-Degree Relatives of Patients Suffering From Schizophrenia

Bär

Berger

Metzner

et al. 2010

Schizophrenia Research

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“…AOR=Adjusted odds ratio; 95% CI=95% confidence interval; SDNN = Standard deviation of all normal RR intervals; RMSSD= Root mean square of successive differences; LF=Low-frequency; HF=High-frequency; LF/HF: The ratio of low to high frequency. (Bar et al, 2005;Birkhofer, Alger, Schmid, & Forstl, 2007;Boettger et al, 2006). In schizophrenia, autonomic dysregulation is associated with more severe psychiatric symptoms, suggesting HRV dysfunction in this disorder may be dependent on the phase of the illness Boettger et al;Henry, Minassian, Paulus, Geyer, & Perry, 2010).…”

Section: Discussionmentioning

confidence: 99%

Heart Rate Variability and Metabolic Syndrome in Hospitalized Patients with Schizophrenia

et al. 2011

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Purpose: Reduced heart rate variability significantly increases cardiovascular mortality. Metabolic syndrome increases the cardiac autonomic dysfunction. Recently, increasing cardiovascular mortality has been reported in patients with schizophrenia. This study was done to compare heart rate variability between adults with and without schizophrenia and to compare the relationship of heart rate variability to metabolic syndrome in hospitalized patients with schizophrenia. Methods: This was a descriptive and correlational study in which 719 adults without schizophrenia and 308 adults with schizophrenia took part between May and June 2008. We measured the following: five-minute heart rate variability; high-frequency, low-frequency, the ratio of low-frequency to high-frequency, and the Standard Deviation of all the normal RR intervals. Data was also collected on metabolic syndrome, abdominal obesity, triglycerides, HDL cholesterol, blood pressure and fasting glucose. Results: The Standard Deviation of all the normal RR intervals values of heart rate variability indices were 1.53±0.18. The low-frequency and high-frequency values of heart rate variability indices were significantly higher in hospitalized patients with schizophrenia (3.89±1.36; 3.80±1.20) than those in the healthy participants (2.20±0.46; 2.10±0.46). There were no significant differences between the schizophrenic patients with and without metabolic syndrome. Conclusion: The results of this study indicate that schizophrenia patients have significantly lower cardiac autonomic control, but they have significantly higher low-frequency and high-frequency values than those of healthy adults. Use of antipsychotic drug may affect the autonomic nervous system in schizophrenic patients. Metabolic syndrome was not associated with cardiac autonomic control in schizophrenia patients.

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“…In addition to these factors, the dysregulation of the autonomic nervous system (ANS) during acute psychosis has become evident for patients with schizophrenia in studies carrying out heart rate variability (HRV) analysis. Studies applying HRV analyses found reduced vagal and increased sympathetic modulation, indicating a cardiac autonomic dysregulation in patients with schizophrenia and partly in their healthy first-degree relatives [6][7][8][9][10][11][12][13]. The pattern of autonomic dysfunction seen in patients and their relatives might indicate underlying diseaseinherent genetic vulnerability, especially as it was shown by Busjahn et al [14] that a genetic dependency of autonomic parameters (HRV) exists.…”

Section: Introductionmentioning

confidence: 99%

High-resolution joint symbolic analysis to enhance classification of the cardiorespiratory system in patients with schizophrenia and their relatives

Schulz

Haueisen

Bär

et al. 2015

Phil. Trans. R. Soc. A.

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Loss of efferent vagal activity in acute schizophrenia

Cited by 160 publications

References 38 publications

Autonomic Dysfunction in Unaffected First-Degree Relatives of Patients Suffering From Schizophrenia

Autonomic Dysfunction in Unaffected First-Degree Relatives of Patients Suffering From Schizophrenia

Heart Rate Variability and Metabolic Syndrome in Hospitalized Patients with Schizophrenia

High-resolution joint symbolic analysis to enhance classification of the cardiorespiratory system in patients with schizophrenia and their relatives

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