Journal of Cell Biology volume 217, issue 1, P195-209 2017 DOI: 10.1083/jcb.201704102 View full text
|
|
Share
Alexander D. Rhys, Pedro Monteiro, Christopher Smith, Malti Vaghela, Teresa Arnandis, Takuya Kato, Birgit Leitinger, Erik Sahai, Andrew McAinsh, Guillaume Charras, Susana A. Godinho

Abstract: Centrosome clustering is essential for the survival of cells containing supernumerary centrosomes. Rhys et al. show that centrosome clustering is a two-step mechanism in which increased cortical contractility, driven by loss of E-cadherin, restricts centrosome movement, facilitating HSET-mediated clustering.