Loss of day-night differences in VIP mRNA levels in the suprachiasmatic nucleus of aged rats

Kawakami, Fumio; Okamura, Hitoshi; Tamada, Yoshitaka; Maebayashi, Yoshiro; Fukui, Kenji; Ibata, Yasuhiko

doi:10.1016/s0304-3940(97)13355-9

Cited by 72 publications

(45 citation statements)

References 18 publications

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“…Such age-related changes cannot be explained by cell death or atrophy in the SCN, as aging does not decrease cell size or numbers in the master pacemaker (Madeira et al, 1995). However, the aged SCN shows alterations in peptide expression (vasoactive intestinal polypeptide (VIP) (Kawakami et al, 1997); arginine vasopressin (AVP) (Roozendaal et al, 1987)), and a reduction in the amplitude of circadian rhythms of electrical activity (Satinoff et al, 1993;Watanabe et al, 1995). Transplantation of a 'young' SCN into aged animals yields improvements in numerous rhythmic functions, including the diurnal rhythm of corticortropin-releasing hormone (CRH) and behavioral rhythms in locomotion (Cai et al, 1997;Li and Satinoff, 1995).…”

Section: Age-related Changes In the Circadian Systemmentioning

confidence: 99%

Aging in the circadian system: Considerations for health, disease prevention and longevity

Gibson

Williams

Kriegsfeld

2009

Experimental Gerontology

138

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The circadian system orchestrates internal physiology on a daily schedule to promote optimal health and maximize disease prevention. Chronic disruptions in circadian function are associated with an increase in a variety of disease states including, heart disease, ulcers, and diabetes. With advanced age, the genes regulating circadian function at the cellar level become disorganized and the ability of the brain clock to entrain to local time diminishes. As a result, aged individuals exhibit a loss of temporal coordination among bodily systems, leading to deficits in homeostasis and sub-optimal functioning. Such disruptions in the circadian system appear to accelerate the aging process and contribute to senescence, with some systems being more vulnerable than others. This review explores aging-associated changes in circadian function and examines evidence linking such alterations to adverse health consequences in late life and promotion of the aging process.

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Section: Age-related Changes In the Circadian Systemmentioning

confidence: 99%

Aging in the circadian system: Considerations for health, disease prevention and longevity

Gibson

Williams

Kriegsfeld

2009

Experimental Gerontology

138

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“…Numerous studies have suggested that the SCN is affected by aging [4,5,18,28,34]. However changes also are observed downstream from the SCN.…”

Section: Locus Of Age-related Changes In the Circadian Systemmentioning

confidence: 99%

“…Indeed, the aged SCN shows a decrease in VIP expression [18], light-induced immediate early gene expression [5,28], and melatonin binding [6]. Electrical rhythmicity, an important output of the clock in the SCN, exhibits a reduced amplitude in slices containing SCN from old hamsters [34] and rats [25].…”

Section: Introductionmentioning

confidence: 99%

“…Because some tissues, although capable of rhythmicity in vitro, do not appear to be rhythmic in vivo [37] and there is evidence for a decrease in the amplitude of both the electrical output [4,25,34] and neurotransmitter expression [18], it is possible that the suprachiasmatic nuclei in aged animals is acting as a weak or unreliable Zeitgeber to peripheral oscillators.…”

Section: Introductionmentioning

confidence: 99%

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Resetting of central and peripheral circadian oscillators in aged rats

Davidson

Yamazaki

Arble

et al. 2008

Neurobiology of Aging

115

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The mammalian circadian timing system is affected by aging. Analysis of the suprachiasmatic nucleus (SCN) and of other circadian oscillators reveals age-related changes which are most profound in extra-SCN tissues. Some extra-SCN oscillators appear to stop oscillating in vivo or display altered phase relationships. To determine whether the dynamic behavior of circadian oscillators is also affected by aging we studied the resetting behavior of the Period1 transcriptional rhythm of peripheral and central oscillators in response to a 6 hr advance or delay in the light schedule. We employed a transgenic rat with a luciferase reporter to allow for real-time measurements of transcriptional rhythmicity. While phase-resetting in the SCN following an advance or a delay of the light cycle appears nearly normal in 2-year old rats, resynchronization of the liver was seriously disrupted. In addition, the arcuate nucleus and pineal gland exhibited faster resetting in aged rats relative to 4-8 month-old controls. The consequences of these deficits are unknown, but may contribute to organ and brain diseases in the aged as well as the health problems that are common in older shift-workers.

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“…Neurobiological changes of the SCN that have been associated with circadian rhythm disruptions in aged animals have included a reduction in the number of cells and the volume of the SCN (Brock 1991;Swaab et al 1985), a decrease in total and rhythmic expression of mRNA for vasoactive intestinal polypeptide in the SCN (Kawakami et al 1997;Krajnak et al 1998), and attenuated c-Fos expression induced by light (Cai et al 1997;Guido et al 1999b;Schwartz et al 1995;Schwartz et al 2000; Takahshi 1993). Although these findings do not discount other possible age-related changes outside the SCN, they do suggest that some changes within the SCN itself could be involved in the circadian rhythm disruptions observed in aged individuals.…”

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confidence: 99%

Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)

Pang

Miller

Fortress

et al. 2006

AGE

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Common complaints of the elderly involve impaired cognitive abilities, such as loss of memory and inability to attend. Although much research has been devoted to these cognitive impairments, other factors such as disrupted sleep patterns and increased daytime drowsiness may contribute indirectly to impaired cognitive abilities. Disrupted sleep-wake cycles may be the result of age-related changes to the internal (circadian) clock. In this article, we review recent research on aging and circadian rhythms with a focus on the senescence-accelerated mouse (SAM) as a model of aging. We explore some of the neurobiological mechanisms that appear to be responsible for our aging clock, and consider implications of this work for age-related changes in cognition.Key words aging . C-Fos . circadian rhythms . mouse . running wheel . SAMP8 . suprachiasmatic nucleus Cognitive impairments are well-known complaints of the elderly. Despite their obvious clinical importance, many questions remain unanswered. One important issue concerns whether cognitive impairments are due to direct alterations in the cognitive function, or to other difficulties that may in turn result in cognitive deficits. For example, the elderly often report poor night-time sleep quality, daytime sleepiness, lack of energy, and difficulty adjusting to a time shift (increased "jet lag"). Could these effects contribute to cognitive impairments?Although a confluence of factors may lead to poor sleep quality, etc., it is likely that one general culprit is aging of the internal (circadian) clock that regulates these behaviors (Munch et al. 2005;Turek et al. 1995;Weitzman et al. 1982). Moreover, evidence suggests that our internal clock may also mediate cognitive functioning (Antoniadis et al. 2000;Brock 1991, Stone 1989van Gool 1986;van Someren et al. 1993a). In this article, we review recent research on aging and circadian rhythms, with a focus on the senescence-accelerated mouse line. We explore some of the neurobiological mechanisms that appear to be responsible for our aging clock, and consider implications of this work for the study of age-related changes in cognition.Circadian rhythms are predictable and regularly occurring daily changes in behavior and physiological states. The term circadian, literally meaning "around a day," has its origins in two Latin words: Circa (around) and dies (day). Two defining characteristics AGE (2006) of circadian rhythms are their continued persistence in the absence of external cues in the environment and their ability to be entrained (synchronized) by environmental cues. With respect to the former property, it is the endogenous (self-sustaining) nature of circadian rhythms that engenders an internal clock. With respect to the latter property, the major external cue that serves to synchronize the circadian rhythms of humans and other mammals is light, but almost any periodic event can act as a Zeitgeber ("time-giver").Research on the biological basis of circadian rhythms in humans and other mammals implicates the s...

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Loss of day-night differences in VIP mRNA levels in the suprachiasmatic nucleus of aged rats

Cited by 72 publications

References 18 publications

Aging in the circadian system: Considerations for health, disease prevention and longevity

Aging in the circadian system: Considerations for health, disease prevention and longevity

Resetting of central and peripheral circadian oscillators in aged rats

Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)

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