Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood. Berlin Diarrhea/Wasting Syndrome Study Group.

Schneider, Thomas; Jahn, H; Schmidt, Wolfgang; Riecken, E. O.; Zeitz, Martin; Ullrich, Reiner

doi:10.1136/gut.37.4.524

Cited by 190 publications

(150 citation statements)

References 24 publications

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“…Recent studies have highlighted the importance of early depletion of CD4 + T cells in the gut occurring after infection of humans with HIV-1 [1][2][3][4][5][6] and rhesus macaques with SIV [7][8][9][10][11]. These authors have observed a rapid and large reduction in the fraction of CD4 + T cells in the lamina propria (LP) of the gut, and several follow-up papers argued that this ''first cut'' is important for disease progression [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Do most lymphocytes in humans really reside in the gut?

Ganusov

Boer

2007

Trends in Immunology

186

147

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Section: Introductionmentioning

confidence: 99%

Do most lymphocytes in humans really reside in the gut?

Ganusov

Boer

2007

Trends in Immunology

186

147

View full text Add to dashboard Cite

“…The lamina propria shows decreased levels of CD4-positive cells and increased levels of CD8-positive cells (reviewed by Riecken et al, 1990). A decrease in CD4-positive cells can be even more pronounced in the lamina propria of intestinal mucosa than the decrease seen in blood (Schneider et al, 1995 ;Snijders et al, 1996). In addition, the mucosal humoral immune system may be compromised in HIV-infected patients (Janoff et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Genetic differences between human immunodeficiency virus type 1 subpopulations in faeces and serum.

Hoek

Sol²,

Maas³

et al. 1998

Journal of General Virology

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To study human immunodeficiency virus type 1 (HIV-1) compartmentalization between intestine and blood, paired faecal and serum samples were collected from 204 HIV-1-infected persons. Direct sequencing of the gp120 V3 region obtained from 33 persons showed that faecal and serum sequences could be nearly homologous (0n3% different) or very dissimilar (11n3 % different). Individual clones were obtained and sequenced from the faecal and serum samples of 13 persons. In 6 persons the HIV-1 subpopulations in faeces and serum were similar, whereas in 7 persons, distribution of V3 genotypes showed a marked difference. Genetic characterization of the HIV-1 subpopulations showed less heterogeneity in faecal subpopulations than in serum subpopulations in 5 of the 7 subjects. Furthermore, faecal and serum

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“…50 Notably, it has been reported that loss of CD4+ T cells in intestinal mucosa precedes the appearance of CD4+ T cell depletion in the peripheral blood of asymptomatic HIV infected patients. 51 Taking into consideration all these findings, it is conceivable that activated memory CD4+ T cells are the preferential target for both HIV-1 infection and apoptosis-mediated CD4+ T lymphocyte depletion in AIDS patients.…”

Section: Discussionmentioning

confidence: 99%

Primary HIV-1 infection of human CD4+ T cells passaged into SCID mice leads to selection of chronically infected cells through a massive Fas-mediated autocrine suicide of uninfected cells

et al. 2000

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We have recently shown that a human CD4+ T cell line (CEM-SS) acquires the permissiveness to M-tropic strains and primary isolates of HIV-1 after transplantation into SCID mice. This permissiveness was associated with the acquisition of a memory (CD45RO+) phenotype as well as of a functional CCR5 coreceptor. In this study, we have used this model for investigating in vivo the relationships between HIV-1 infection, apoptosis and T cell differentiation. When an in vivo HIV-1 infection was performed, the CEM cell tumors grew to a lower extent than the uninfected controls. CEM cells explanted from uninfected SCID mice (ex vivo CEM) underwent a significant level of spontaneous apoptosis and proved to be CD45RO+, Fas+ and Fas-L+, while Bcl-2 expression was significantly reduced as compared to the parental cells. Acute HIV-1 infection markedly increased apoptosis of uninfected ex vivo CEM cells, through a Fas/Fas-L-mediated autocrine suicide/ fratricide, while parental cells did not undergo apoptosis following viral infection. The susceptibility to apoptosis of ex vivo CEM cells infected with the NSI strain of HIV-1, was progressively lost during culture, in parallel with the loss of Fas-L and marked changes in the Bcl-2 cellular distribution. On the whole, these results are strongly reminiscent of a series of events possibly occurring during HIV-1 infection. After an initial depletion of bystander CD4+ memory T cells during acute infection, latently or chronically infected CD4+ T lymphocytes are progressively selected and are protected against spontaneous apoptosis through the development of an efficient survival program. Studies with human cells passaged into SCID mice may offer new opportunities for an in vivo investigation of the mechanisms involved in HIV-1 infection and CD4+ T cell depletion. Cell Death and Differentiation (2000) 7, 37 ± 47.

show abstract

Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood. Berlin Diarrhea/Wasting Syndrome Study Group.

Cited by 190 publications

References 24 publications

Do most lymphocytes in humans really reside in the gut?

Do most lymphocytes in humans really reside in the gut?

Genetic differences between human immunodeficiency virus type 1 subpopulations in faeces and serum.

Primary HIV-1 infection of human CD4+ T cells passaged into SCID mice leads to selection of chronically infected cells through a massive Fas-mediated autocrine suicide of uninfected cells

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