Loss of BRCA1-associated protein 1 ( BAP1 ) expression is rare in non–small cell lung cancer

Owen, Daniel R.; Sheffield, Brandon S.; Ionescu, Diana N.; Churg, Andrew

doi:10.1016/j.humpath.2016.10.005

Cited by 30 publications

(17 citation statements)

References 16 publications

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“…As a matter of interest, we also asked whether MTAP immunohistochemistry might be of diagnostic use in lung adenocarcinomas and high-grade serous carcinomas, tumors in which BAP1 loss is sufficiently rare (,1% of cases) that the finding of BAP1 loss is strong evidence against either diagnosis. 18,19 For comparison, 21 adenocarcinomas of the lung were stained and showed 14% MTAP loss, as were 12 high-grade ovarian serous carcinomas, which showed 8% MTAP loss. MTAP immunohistochemistry thus does not appear to be useful in either setting.…”

Section: Discussionmentioning

confidence: 99%

Utility of Methylthioadenosine Phosphorylase Compared With BAP1 Immunohistochemistry, and CDKN2A and NF2 Fluorescence In Situ Hybridization in Separating Reactive Mesothelial Proliferations From Epithelioid Malignant Mesotheliomas

Berg

Đačić

Miller

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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100

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Section: Discussionmentioning

confidence: 99%

Utility of Methylthioadenosine Phosphorylase Compared With BAP1 Immunohistochemistry, and CDKN2A and NF2 Fluorescence In Situ Hybridization in Separating Reactive Mesothelial Proliferations From Epithelioid Malignant Mesotheliomas

Berg

Đačić

Miller

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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100

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“…Chromosomal deletions and somatic inactivating mutations have been identified at high frequency in uveal melanoma ( Harbour et al, 2010 ), clear cell renal carcinoma ( Peña-Llopis et al, 2012 ) and cholangiocarcinoma ( Fujimoto et al, 2015 ), increasing the potential clinical impact of our discovery. Although loss of BAP1 function is seen at far lower rates in breast carcinoma (1%) ( Stephens et al, 2012 ) and non-small cell lung carcinoma (1%) ( Owen et al, 2017 ), the high incidence of these cancers translates to a large cohort of patients.…”

Section: Discussionmentioning

confidence: 99%

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

Kolluri

Alifrangis

Kumar

et al. 2018

eLife

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Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal. Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of a subset defined by loss of function of the nuclear deubiquitinase BRCA associated protein-1 (BAP1) that demonstrate heightened sensitivity to TRAIL (tumour necrosis factor-related apoptosis-inducing ligand). This association is observed across human early passage MM cultures, mouse xenografts and human tumour explants. We demonstrate that BAP1 deubiquitinase activity and its association with ASXL1 to form the Polycomb repressive deubiquitinase complex (PR-DUB) impacts TRAIL sensitivity implicating transcriptional modulation as an underlying mechanism. Death receptor agonists are well-tolerated anti-cancer agents demonstrating limited therapeutic benefit in trials without a targeting biomarker. We identify BAP1 loss-of-function mutations, which are frequent in MM, as a potential genomic stratification tool for TRAIL sensitivity with immediate and actionable therapeutic implications.

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“…BAP1 is an important nuclear ubiquitin hydrolase involved in the cell cycle regulation, cell proliferation, cellular differentiation, repair of DNA damage, and apoptosis [ 40 ]. Ubiquitin C-terminal hydrolase was found to be involved in sex differentiation in fish [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

De novo transcriptome sequencing and analysis of male and female swimming crab (Portunus trituberculatus) reproductive systems during mating embrace (stage II)

Wang¹,

Sun²,

Guan

et al. 2018

BMC Genet

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BackgroundThe swimming crab Portunus trituberculatus is one of the most commonly farmed crustaceans in China. As one of the most widely known and high-value edible crabs, it crab supports large crab fishery and aquaculture in China. Only large and sexually mature crabs can provide the greatest economic benefits, suggesting the considerable effect of reproductive system development on fishery. Studies are rarely conducted on the molecular regulatory mechanism underlying the development of the reproductive system during the mating embrace stage in this species. In this study, we used high-throughput sequencing to sequence all transcriptomes of the P. trituberculatus reproductive system.ResultsTranscriptome sequencing of the reproductive system produced 81,688,878 raw reads (38,801,152 and 42,887,726 reads from female and male crabs, respectively). Low-quality (quality <20) reads were trimmed and removed, leaving only high-quality reads (37,020,664 and 41,021,030 from female and male crabs, respectively). A total of 126,188 (female) and 164,616 (male) transcripts were then generated by de novo transcriptome assembly using Trinity. Functional annotation of the obtained unigenes revealed that a large number of key genes and some important pathways may participate in cell proliferation and signal transduction. On the basis of our transcriptome analyses and as confirmed by quantitative real-time PCR, a number of genes potentially involved in the regulation of gonadal development and reproduction of P. trituberculatus were identified: ADRA1B, BAP1, ARL3, and TRPA1.ConclusionThis study is the first to report on the whole reproductive system transcriptome information in stage II of P. trituberculatus gonadal development and provides rich resources for further studies to elucidate the molecular basis of the development of reproductive systems and reproduction in crabs. The current study can be used to further investigate functional genomics in this species.Electronic supplementary materialThe online version of this article (10.1186/s12863-017-0592-5) contains supplementary material, which is available to authorized users.

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Loss of BRCA1-associated protein 1 ( BAP1 ) expression is rare in non–small cell lung cancer

Cited by 30 publications

References 16 publications

Utility of Methylthioadenosine Phosphorylase Compared With BAP1 Immunohistochemistry, and CDKN2A and NF2 Fluorescence In Situ Hybridization in Separating Reactive Mesothelial Proliferations From Epithelioid Malignant Mesotheliomas

Utility of Methylthioadenosine Phosphorylase Compared With BAP1 Immunohistochemistry, and CDKN2A and NF2 Fluorescence In Situ Hybridization in Separating Reactive Mesothelial Proliferations From Epithelioid Malignant Mesotheliomas

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

De novo transcriptome sequencing and analysis of male and female swimming crab (Portunus trituberculatus) reproductive systems during mating embrace (stage II)

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