Loss of Basement Membrane Integrity in Human Gingival Overgrowth

Abstract

Gingival overgrowth tissues have thickened connective tissue stroma, sometimes accompanied by the increased presence of collagen fibers, thickened epithelia, and elongated rete pegs. We have previ

Drug-induced gingival overgrowth: The nemesis of gingiva unravelled

“…Kantarci et al .,[20] demonstrated that there are significantly higher numbers of basement membrane discontinuities in overgrowth tissues, sometimes containing epithelial-like cells. Disrupted basal membrane structure in gingival overgrowth tissues is accompanied by a discontinuous collagen type IV expression pattern and decreased laminin-5.…”

“…These findings provided a new additional support for the hypothesis that epithelial plasticity and epithelial to mesenchymal transition promote gingival overgrowth, resulting in compromised basal membrane structure and increased interactions between epithelial and connective tissue layers that contribute to fibrotic pathology. [2021]…”

Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients

“…Drug‐induced gingival overgrowth was previously termed ‘gingival hypertrophy’ or ‘gingival hyperplasia’, but these terms do not accurately reflect the histological composition of the enlarged gingiva, as the number of fibroblasts is not appreciably increased, but there is a severe accumulation of extracellular matrix within the gingival connective tissue. In addition to fibrosis, DIGO is also accompanied by thickening of the gingival epithelium (Kataoka et al , 2005; Kantarci et al , 2011), and in rat models, there is hypertrophy of the epithelial stratum spinosum with hyperplasia of the junctional epithelium (Ayanoglou and Lesty, 1999).…”

Prevalence of Gingival Hyperplasia Secondary to Amlodipine

“…These findings provided a new additional support for the hypothesis that epithelial plasticity and epithelial to mesenchymal transition promote gingival overgrowth, resulting in compromised basal membrane structure and increased interactions between epithelial and connective tissue layers that contribute to fibrotic pathology. 19,20 Recently, Subramani et al observed that mast cells participate in many inflammatory oral diseases, particularly those associated with fibrosis. 21 They possess very diverse roles ranging from proinflammatory to immunomodulatory.…”