“…In affected members of a large French family with ADHSP, it has been identified a heterozygous missense mutation in the REEP2 gene (Esteves et al, 2014) (Tables 1 and 2). ARHSP Forty-eight SPG loci and 41 genes responsible for ARHSP have been identified so far. Several other ARHSP loci, namely SPG14 (Vazza et al, 2000), SPG23 (Blumen et al, 2003), SPG24 (Hodgkinson et al, 2002), SPG25 (Zortea et al, 2002), SPG27 (Meijer et al, 2004;Ribaï et al, 2006), SPG32 (Stevanin et al, 2007a), and SPG45 (Dursun et al, 2009), have been identified but pathological genes are yet unknown (Tables 1 and 2).…”