Loss of an X chromosome in aggressive angiomyxoma of female soft parts: A case report

Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literature

“…Abnormal cytogenetic findings of only seven cases of aggressive angiomyxoma have been reported to date [11][12][13][14][15][16][17][18][19]. Here, we report the conventional cytogenetic, molecular cytogenetic, and immunohistochemical findings of an aggressive angiomyxoma arising in the rectal wall of a 72 year-old female.…”

“…Cytogenetic abnormalities have been identified in seven cases of aggressive angiomyxoma to date, Table 1 [11][12][13][14][15][16][17][18][19]. Abnormalities of chromosome 12 were detected in six of these cases with specific involvement of the 12q13-15 region in five.…”

A solitary encapsulated pelvic aggressive angiomyxoma

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Its radiological features have been described, being a displacing mass rather than infiltrating, with high signal intensity on T2-weighted images, 1,14,15 but these features can be attributed to the myxoid component of the tumour, shown by many other soft tissue tumours of mesenchymal origin. On gross examination, it was different in being well circumscribed non-lobulated and encapsulated, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] but the gelatinous appearance, greyish discoloration on cross section and the large size of the tumour are common features of AAMs. These findings are attributed to the myxoid stroma that is rich in collagen fibres.…”

“…4,18 Complete excision is the treatment of choice. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] We believe that 1-2 yearly intervals of follow-up with alternate MRI and sonography is sufficient in view of the slow growing and nonmetastasising nature of this tumour.…”

“…The cytologic and architectural similarities of this tumour with the normal stroma of the vulvar, perineal and pelvic region add to the debate on the line of differentiation. [1][2][3] Clonal cytogenic aberrations have been reported in some aggressive angiomyxomas, 1 including loss of an X chromosome 16 and a translocation involving 12q14-15. 17 The latter has been frequently seen in a variety of other mesenchymal tumours and it seemed to be the most frequent chromosomal abnormality associated with irritation of human mesenchymal neoplasms.…”