2016
DOI: 10.18632/oncotarget.9154
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Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway

Abstract: Absent in melanoma (AIM2) is a member of the interferon-inducible HIN-200 protein family and is recently recognized to play an important dual role in both innate immunity and tumor pathology. However, the role of AIM2 in the development of hepatocellular carcinoma (HCC) remains to be clarified. Here we showed that AIM2 expression was significantly decreased in liver cancer tissues, and loss of its expression was significantly correlated with more advanced tumor progression. Exogenous overexpression of AIM2 in … Show more

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Cited by 89 publications
(110 citation statements)
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References 26 publications
(27 reference statements)
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“…In line with our data, Ma et al . (2016) showed that AIM2 was down‐regulated in 113 HCC cases recruited from North China. Patients with low expression of AIM2 had a shorter life compared to those with high AIM2 expression.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In line with our data, Ma et al . (2016) showed that AIM2 was down‐regulated in 113 HCC cases recruited from North China. Patients with low expression of AIM2 had a shorter life compared to those with high AIM2 expression.…”
Section: Discussionmentioning
confidence: 99%
“…Excessive AIM2 expression inhibited cell proliferation and induced apoptosis in breast carcinoma (Chen et al ., 2006; Liu et al ., 2015b). Interestingly, AIM2 expression was elevated in chronic hepatitis B (CHB) patients (Han et al ., 2015) and decreased in HCC patients (Ma et al ., 2016). However, the clinical significance of AIM2 in HCC and the mechanism of its downregualtion have not been demonstrated.…”
Section: Introductionmentioning
confidence: 99%
“…Reconstitution of AIM2 expression in HCC cell lines had an inhibitory effect on mTOR and S6K1 phosphorylation that was reversed by caspase‐1 inhibition. Reconstitution of AIM2 expression also impaired tumor growth in a HCC xenograft model . In a different mouse model of HCC, decreased AIM2 expression led to increased number of liver tumors and lung nodules .…”
Section: Aim2 In Health and Diseasementioning
confidence: 92%
“…In liver samples from patients with HCC, AIM2 expression was decreased in cancer tissue compared to corresponding non‐cancerous samples. Moreover, AIM2 expression was negatively correlated with tumor volume, grade, and metastatic progression . In liver, hepatitis B virus X protein (HBx) has been proposed to contribute to the downregulation of AIM2 expression both at the transcription and protein levels.…”
Section: Aim2 In Health and Diseasementioning
confidence: 99%
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