Cell Reports volume 5, issue 4, P926-932 2013 DOI: 10.1016/j.celrep.2013.10.021 View full text
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Sadanori Watanabe, Tihana De Zan, Toshimasa Ishizaki, Shingo Yasuda, Hiroshi Kamijo, Daisuke Yamada, Tomohiro Aoki, Hiroshi Kiyonari, Hiroshi Kaneko, Ritsuko Shimizu, Masayuki Yamamoto, Gohta Goshima, Shuh Narumiya

Abstract: The small GTPase Rho and mDia2, a Rho-regulated actin nucleator, function as critical regulators of cytokinesis in cultured cells. However, their involvement in cytokinesis during mammalian development remains unknown. Here, we generated mice deficient in mDia2 and examined the role of Rho signaling in cytokinesis during development. mDia2-deficient mice survive until embryonic day 11.5 (E11.5), exhibit severe anemia with multinucleate erythroblasts, and die in utero by E12.5. mDia2-deficient erythroid cells d…

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