Losartan prevents the imbalance between renal dopaminergic and renin angiotensin systems induced by fructose overload. l-Dopa/dopamine index as new potential biomarker of renal dysfunction

Mikusic, Natalia Lucía Rukavina; Kouyoumdzian, Nicolás Martín; Uceda, Ana; Mauro, Julieta S. Del; Pandolfo, Marcela; Gironacci, Mariela M.; Puyó, Ana María; Toblli, Jorge Eduardo; Fernández, Belisario E.; Choi, Marcelo Roberto

doi:10.1016/j.metabol.2018.04.010

Cited by 18 publications

(12 citation statements)

References 54 publications

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“…In fact, losartan has been shown to be able to enhance ACE2 expression in vivo [111] , preventing the superinfections associated with coronaviruses [110] . In addition, losartan also mitigates COVID-19 symptoms by inhibiting TNF-α, IL-6 and IL-1β production [106] , and reducing NFκB and p38MAPK activation [112] , [113] , thereby attenuating the inflammatory process. This ARB could, therefore, reduce the excessively high levels of PICs that have a harmful role in the outcomes of COVID-19 patients.…”

Section: Drug Repurposing For Covid-19 and Affected Cytokinesmentioning

confidence: 99%

Drug repurposing and cytokine management in response to COVID-19: A review

Heimfarth

Serafini

Martins-Filho

et al. 2020

International Immunopharmacology

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Highlights Rational strategy to carry out drugs repurposing for management COVID-19 patients. Anti-inflammation therapy plays a pivotal role in the management COVID-19 patients. Drugs mitigate the cytokines production induced by SARS-CoV-2‘s immunological activation. Reduction in hyperinflammation lead to a decrease in multiple organ failure.

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Section: Drug Repurposing For Covid-19 and Affected Cytokinesmentioning

confidence: 99%

Drug repurposing and cytokine management in response to COVID-19: A review

Heimfarth

Serafini

Martins-Filho

et al. 2020

International Immunopharmacology

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“…These effects were reproduced in an experimental in vivo model, in which the infusion of ANP at low doses increased the urinary excretion of dopamine by stimulating the activity of OCTs with subsequent over-inhibition of the Na + , K + -ATPase ( Kouyoumdzian et al, 2016 ). Additionally, Ang II opposes to ANP by downregulating the renal dopaminergic system ( Rukavina Mikusic et al, 2018a ; Kouyoumdzian et al, 2021 ). This synergic interaction between ANP and renal dopamine not only favors the maintenance of hydro-electrolyte balance, blood pressure, and a stable redox state, but also its alteration would be implicated in the pathophysiology of arterial hypertension and inflammatory renal damage ( Armando et al, 2011 ; Choi et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Protective Renal Effects of Atrial Natriuretic Peptide: Where Are We Now?

Choi

Fernández

2021

Front. Physiol.

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Atrial natriuretic peptide belongs to the family of natriuretic peptides, a system with natriuretic, diuretic, and vasodilator effects that opposes to renin-angiotensin system. In addition to its classic actions, atrial natriuretic peptide exerts a nephroprotective effect given its antioxidant and anti-inflammatory properties, turning it as a beneficial agent against acute and chronic kidney diseases. This minireview describes the most relevant aspects of atrial natriuretic peptide in the kidney, including its renal synthesis, physiological actions through specific receptors, the importance of its metabolism, and its potential use in different pathological scenarios.

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“…Losartan was originally used for treatment of hypotension, although it was also reported to have cardiovascular (54,55) and renal protective effects (56) unrelated to blood pressure. Cerebrovascular hemodynamic changes are often observed following TBI, which are associated with poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Losartan Treatment Could Improve the Outcome of TBI Mice

Xiong

Gao

et al. 2020

Front. Neurol.

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Traumatic brain injury frequently leads to serious mortality and physical disability, yet effective treatments remains insufficient. TBI always leads to a series of secondary brain injuries including neuronal apoptosis, continuous inflammation, endoplasmic reticulum stress, and disruption of the blood-brain barrier. Sartans that block angiotensin II type 1 receptors are strongly neuroprotective, neurorestorative and anti-inflammatory. However, whether losartan, a FDA-approved and widely used drug for regulating blood pressure, is beneficial for improving the prognosis of TBI need more evidence. Through a controlled cortical impact injury mice model, we confirmed that losartan treatment could ameliorate CCI-induced secondary brain injury. We found that losartan treatment decreased brain lesion volume, neuronal apoptosis and ER stress protein ATF4 and eIF2α. Moreover, our results showed that losartan also improved neurological and motor function. It is worth pointing out that losartan increased the expression of tight junction proteins ZO-1 and alleviated brain edema and blood brain barrier leakage. Additionally, losartan inhibited pro-inflammatory factor TNF-α and improve anti-inflammatory factor IL-10. Taken together, our data demonstrated that losartan could improve the prognosis of TBI and may be a promising therapeutic method for mitigating TBI.

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Losartan prevents the imbalance between renal dopaminergic and renin angiotensin systems induced by fructose overload. l-Dopa/dopamine index as new potential biomarker of renal dysfunction

Cited by 18 publications

References 54 publications

Drug repurposing and cytokine management in response to COVID-19: A review

Drug repurposing and cytokine management in response to COVID-19: A review

Protective Renal Effects of Atrial Natriuretic Peptide: Where Are We Now?

Losartan Treatment Could Improve the Outcome of TBI Mice

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