Lornoxicam and ondansetron for the prevention of intrathecal fentanyl-induced pruritus

Gülhaş, Nurçin; Erdil, Feray; Sağır, Özlem; Gedik, Ender; Toğal, Türkan; Begeç, Zekine; Ersoy, M. Özcan

doi:10.1007/s00540-007-0503-4

Cited by 20 publications

(31 citation statements)

References 18 publications

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“…Administration of ondansetron was performed before neuraxial anesthesia in 4 studies [22][23][24][25] and intraoperatively after neuraxial anesthesia in 2 studies. [26][27][28][29] Placebo or control treatment was the administration of IV normal saline in 5 studies, and no intervention in 1 study. 29 Intrathecal opioids were administered as part of combined spinal-epidural anesthesia in the 2 studies involving obstetric patients 22,26,27 and as part of spinal injection in 4 studies.…”

Section: Study Intervention and Pruritus Assessmentmentioning

confidence: 99%

“…[26][27][28][29] Placebo or control treatment was the administration of IV normal saline in 5 studies, and no intervention in 1 study. 29 Intrathecal opioids were administered as part of combined spinal-epidural anesthesia in the 2 studies involving obstetric patients 22,26,27 and as part of spinal injection in 4 studies. [23][24][25]28,29 All patients were blinded to the study intervention.…”

Section: Study Intervention and Pruritus Assessmentmentioning

confidence: 99%

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Prophylactic Ondansetron for the Prevention of Intrathecal Fentanyl- or Sufentanil-Mediated Pruritus

Prin

Guglielminotti²,

Moitra

et al. 2016

Anesthesia &Amp; Analgesia

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Section: Study Intervention and Pruritus Assessmentmentioning

confidence: 99%

Section: Study Intervention and Pruritus Assessmentmentioning

confidence: 99%

Prophylactic Ondansetron for the Prevention of Intrathecal Fentanyl- or Sufentanil-Mediated Pruritus

Prin

Guglielminotti²,

Moitra

et al. 2016

Anesthesia &Amp; Analgesia

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“…Todo ello mejora la transmisión de las fibras C en el sistema nervioso central, lo que potencia el prurito (15). Una densidad alta de receptores 5-HT3 (subtipo 5-hidroxitriptamina 3) y receptores mu están presentes en las capas superficiales del asta dorsal y en el núcleo del tracto espinal del nervio trigémino en la médula espinal.…”

Section: Mecanismo Del Pruritounclassified

Actualización en el manejo del prurito inducido por opioides neuraxiales

Bujedo¹

2016

Rev. Soc. Esp. Dolor.

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Instrucciones de citación para el artículo:Mugabure Bujedo Borja. Actualización en el manejo del prurito inducido por opioides neuraxiales. Rev. Soc. Esp. Dolor. 2016. doi: 10.20986/resed.2016.3541/2016 Este es un archivo PDF de un manuscrito inédito que ha sido aceptado para su publicación en la Revista de la Sociedad Española del Dolor. Como un servicio a nuestros clientes estamos proporcionando esta primera versión del manuscrito en estado de prepublicación. El manuscrito será sometido a la corrección de estilo final, composición y revisión de la prueba resultante antes de que se publique en su forma final. Tenga en cuenta que durante el proceso de producción se pueden dar errores lo que podría afectar el contenido final. El copyright y todos los derechos legales que se aplican al artículo pertenecen a la Revista de la Sociedad Española de Dolor. ACTUALIZACIÓN EN EL MANEJO DEL PRURITO INDUCIDO POR OPIOIDES NEURAXIALES AN UPDATE IN THE MANAGEMENT OF NEURAXIAL OPIOID INDUCED PRURITUS B. Mugabure Bujedo Servicio de Anestesiología Reanimación y Tratamiento del dolor. Hospital Universitario Donostia, San Sebastián CORRESPONDENCIA:Borja Mugabure Bujedo mugabure@yahoo.es Recibido 12-11-2016 Aceptado 15-12-2016 ABSTRACTThe itching or pruritus is a secondary effect very annoying that appears after the neuroaxial administration (epidural or intrathecal) of opioid drugs. Sometimes it can even be more unpleasant that the own pain by itself. Either prevention or treatment remains a challenge in the clinical practice of care for these patients. A wide variety of medications with different mechanisms of action have been used and focused in its management, with widely varying results. The objective of this article is to review the literature and summarize the current evidence of the mechanisms and pharmacological treatments available to handle pruritus induced by spinal opioids. The source of articles of this review was obtained through PubMed, Medline and Scopus until December 2016. These search results have been limited to the randomized controlled trials, systematized or comprehensive reviews and from opinion articles of experts in the subject. The most useful drugs are opioid mu antagonists, as naloxone, and mixed opioids kappa agonists /mu antagonists, as nalbuphine and butorphanol, the latter being able in addition to maintaining the analgesia. They have also shown some effectiveness, but to a lesser degree, from receptor antagonists of the serotonin 5-HT3, as ondasetron, administered prophylactically, and the antagonists of dopaminergic receptors D2, as dehidrobenzoperidol. Finally subanesthetic low dose of propofol and prophylactic oral mitarzapine and gabapentin have been used with medium results.Key words: Neuraxial opioids, itching, pruritus, postoperative complications, epidural, intradural, mu and kappa opioid receptors. RESUMENEl picor o prurito es un efecto secundario muy molesto que aparece tras la administración neuroaxial (epidural e intratecal) de fármacos opioides. A veces puede ser incluso más desagr...

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“…Tenoxicam [40] and rectal diclofenac [41] possess certain anti-pruriginous effects in patients receiving spinal opioids. However, Gulhas et al [42] found no decrease of pruritus with the use of lornoxicam after administration of intrathecal fentanyl. The Celecoxib, a selective COX-2, has shown variable results in studies on anti-pruriginous effects.…”

Section: Other Drugs Nsaidsmentioning

confidence: 99%

“…In this narrative review, practical information for correct spinal opioid selection is provided to help the physicians a better approach to postoperative multimodal spinal analgesia [6][7][8][9][10][11][12][13]. Morphine could be the primary opioid involved in the presence of NO adverse effects such as pruritus, urinary retention, PONV and delayed respiratory depression [14,15].…”

Section: Clinical Use Of Neuraxial Opioidsmentioning

confidence: 99%

Untitled

2016

JACCOA

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Lornoxicam and ondansetron for the prevention of intrathecal fentanyl-induced pruritus

Abstract: We observed that the administration of 8 mg IV lornoxicam failed to prevent intrathecal fentanyl-induced pruritus in parturients. Also, our data confirmed that ondansetron is likely to attenuate intrathecal fentanyl-induced pruritus.

Cited by 20 publications

References 18 publications

Prophylactic Ondansetron for the Prevention of Intrathecal Fentanyl- or Sufentanil-Mediated Pruritus

Prophylactic Ondansetron for the Prevention of Intrathecal Fentanyl- or Sufentanil-Mediated Pruritus

Actualización en el manejo del prurito inducido por opioides neuraxiales

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