1983
DOI: 10.1093/bja/55.4.275
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Lorazepam in Children

Abstract: SUMMARYOne hundred patients aged 5-13yr were randomly allocated to four groups in a double-blind study of premedication. Drugs studied were lorazepam, diazepam and trimeprazine. A placebo group was included. All the drugs appeared satisfactory as premedicants. Lorazepam induced the most sedation immediately after surgery, but by 4 h lorazepam and diazepam appeared similar. Lorazepam produced better amnesia than the other drugs. There were no untoward side-effects and no cardiorespiratory depression in any grou… Show more

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Cited by 26 publications
(6 citation statements)
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“…Benzodiazepines used alone were compared to placebos in 17 studies [7,18,19,3133,35,36,40,52,58,59,63, 64,66,68,69], twelve of which were included in the meta-analysis. The remaining trials were excluded because it was impossible to group the data [40,52,63] or there was an overall high risk of bias [64] or after the sensitivity analysis [35].…”
Section: Resultsmentioning
confidence: 99%
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“…Benzodiazepines used alone were compared to placebos in 17 studies [7,18,19,3133,35,36,40,52,58,59,63, 64,66,68,69], twelve of which were included in the meta-analysis. The remaining trials were excluded because it was impossible to group the data [40,52,63] or there was an overall high risk of bias [64] or after the sensitivity analysis [35].…”
Section: Resultsmentioning
confidence: 99%
“…Benzodiazepines were compared to each other in 17 studies [7,18,27,29,31,39,41,43,53,54,55,57,59,61,62,64,67]. Six of these studies compared different benzodiazepines [18,39,43,53,57,62], six compared dosages [29,31,41,55,61,64], one compared the time of administration [7], and 4 compared routes [27,54,59,67].…”
Section: Resultsmentioning
confidence: 99%
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