Lophocladines, Bioactive Alkaloids from the Red Alga Lophocladia sp.

Gross, Harald; Goeger, Douglas E.; Hills, Patrice; Mooberry, Susan L.; Ballantine, David L.; Murray, Thomas F.; Valeriote, Frederick A.; Gerwick, William H.

doi:10.1021/np050519e

Cited by 92 publications

(64 citation statements)

References 29 publications

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“…L. lallemandii is highly abundant in the community while it is scarce in gut contents and therefore Ivlev's index is negative. Sea urchins may avoid L. lallemandi because it contains lophocladines, alkaloids with cytotoxic effects (Gross et al 2006), which are not present in any native algal species. In contrast, the high abundance of C. racemosa in the sea urchin gut contents and a positive Ivlev's index indicate that this species is actively consumed.…”

Section: Discussionmentioning

confidence: 99%

Do native herbivores provide resistance to Mediterranean marine bioinvasions? A seaweed example

et al. 2010

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Generalist herbivores in marine ecosystems are poorly examined for their potential to serve as a source of biotic resistance against algal invasion. We assessed how one of the main generalist herbivores in Mediterranean rocky reefs (the sea urchin Paracentrotus lividus) affects Lophocladia lallemandii and Caulerpa racemosa, two algal invaders with strong detrimental effects on native benthic communities. In a comparison of sea urchin gut contents to algal community composition, strong preferences were exhibited, leading to no relationship between consumption and availability. Both C. racemosa and L. lallemandi were abundant in algal assemblages (>60% occurrence), but C. racemosa (20% of diet) was consumed more than L. lallemandi (3.5%). Experimental enclosures of sea urchins (12 sea urchins * m−2) were carried out in locations where L. lallemandii was already established and C. racemosa was rare (new invasion) or abundant (established invasion). C. racemosa was negatively affected by sea urchins only when it was rare, and no effect was detected when the alga was already abundant. Results for L. lallemandi were exactly opposite: urchins limited seasonal increases in L. lallemandi in highly-invaded areas. Because of the small amount of direct consumption of L. lallemandi, its decrease in abundance may be related to the grazing of native algae where L. lallemandii is attached. Overall, our results show that high densities of native herbivores may reduce invasive algae at low densities, due to a combination of direct and indirect effects, but it has no significant effect in highly-invaded area

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Section: Discussionmentioning

confidence: 99%

Do native herbivores provide resistance to Mediterranean marine bioinvasions? A seaweed example

et al. 2010

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“…Given that seagrass blades are tougher than the thin filamentous thallii of L. lallemandii, W. setacea and A. preissii, differences in feeding behaviour are likely driven by chemical characteristics. Lophocladia species produce alkaloids with cytotoxic effects (Gross et al 2006), which could act as a defense mechanism against herbivores, but the presence of secondary metabolites in W. setacea and A. preissii is unknown. However, the highest diversity of secondary metabolites is found among rodophytes, and algae from the family Rhodomelacea (which includes Womersleyella spp.)…”

Section: Discussionmentioning

confidence: 99%

Effects of invasive seaweeds on feeding preference and performance of a keystone Mediterranean herbivore

2010

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The consequences of invasive species on ecosystem processes and ecological interactions remain poorly understood. Predator-prey interactions are fundamental in shaping species evolution and community structure and can be strongly modified by species introductions. To fully understand the ecological effects of invasive species on trophic linkages it is important to characterize novel interactions between native predators and exotic prey and to identify the impacts of invasive species on the performance of native predators. Although seaweed invasions are a growing global concern, our understanding of invasive algae-herbivore interactions is still very limited. We used a series of feeding experiments between a native herbivore and four invasive algae in the Mediterranean Sea to examine the potential of native sea urchins to consume invasive seaweeds and the impacts of invasive seaweed on herbivore performance. We found that three of the four invasive species examined are avoided by native herbivores, and that feeding behaviour in sea urchins is not driven by plant nutritional quality. On the other hand, Caulerpa racemosa is readily consumed by sea urchins, but may escape enemy control by reducing their performance. Recognizing the negative impacts of C. racemosa on herbivore performance has highlighted an enemy escape mechanism that contributes to explaining how this widespread invasive alga, which is preferred and consumed by herbivores, is not eradicated by grazing in the field. Furthermore, given the ecological and economic importance of sea urchins, negative impacts of invasive seaweeds on their performance could have dramatic effects on ecosystem function and services, and should be accounted for in sea urchin population management strategies.

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“…2f) isolated from red alga Lophocladia showed a remarkable cytotoxicity and cell cycle arrest of NCI-H460 human lung tumor and MDA-MB-435 breast cancer cell lines (Table 2). Cells in the G 1 and S phases with an accumulation of cells in G 2 /M, signaling a G 2 /M cell cycle arrest [41].…”

Section: Lophocladiamentioning

confidence: 99%

Algae as potential repository of anti cancerous natural compounds

Mridha¹,

Paul²

2017

ijpm

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Algae constitute a promising source of novel compounds with potential as human therapeutic agents. In particular, algae have been considered as a potential source of new bio-active compound. Algae possess several biological activities, including anticancer activity. This review provides a comprehensive report on the several genera of algae belonging to Chlorophyceae, Pheophyceae and Rhodophyceae having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action in vitro as well as in vivo condition. Algae are extensively used as functional foods and medicinal herbs, and have a long history of use in Asian countries. Many algae have been used for the treatment of cancer, many crude or partially purified polysaccharides from various brown, green, and red algae have been tested for their antitumor activities. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Science Direct, and Scopus. The different extracts with some other solvent shows a huge anti-proliferative action on different cancer as well as on different leukemia cell lines. Here we focus on several bioactive compounds that have been derived as well as characterized from different genera of algae and there mechanism of inhibiting cancer cell growth. Considering the ability of the golden treasure present in algae to act against different cancers, this review highlights the potential use of algae as anticancer agents.

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Lophocladines, Bioactive Alkaloids from the Red Alga Lophocladia sp.

Cited by 92 publications

References 29 publications

Do native herbivores provide resistance to Mediterranean marine bioinvasions? A seaweed example

Do native herbivores provide resistance to Mediterranean marine bioinvasions? A seaweed example

Effects of invasive seaweeds on feeding preference and performance of a keystone Mediterranean herbivore

Algae as potential repository of anti cancerous natural compounds

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