Loose versus stranded seeds in permanent prostate brachytherapy: Dosimetric comparison of intraoperative plans

Major, Tibor; Ágoston, Péter; Fröhlich, Georgina; Baricza, Károly; Szabó, Z. G.; Jorgo, Kliton; Herein, András; Polgár, Csaba

doi:10.1016/j.ejmp.2014.08.002

Cited by 8 publications

(8 citation statements)

References 31 publications

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“…Highly precise seed implantation is more likely to be achieved with loose seeds than stranded seeds. Some reports concluded that rectal and urethral doses were better in the loose seed group than the stranded seed group 10,13 . The dose coverage of the prostate was also similar or better with loose seeds 7–12 .…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9][10][11][12] These previous studies compared dosimetric parameters between a loose seed and a stranded seed group. [7][8][9][10]12 One study used a hybrid method. 11 We investigated whether the hybrid method achieved better dose coverage of the prostate plus 3-and 5-mm margins while complying with the rectal and urethral dose restrictions compared with the conventional method (using only loose seeds).…”

Section: Discussionmentioning

confidence: 99%

“…Several previous studies compared the dosimetric parameters between stranded and loose seeds. [7][8][9][10][11][12] We started the hybrid method using stranded seeds for the peripheral needles and loose seeds for the internal needles to maximize the strengths and minimize the limitations of each type of seed. We also carried out a randomized controlled trial to compare the post-implant dosimetric parameters between the conventional method (using only the loose seeds) and the hybrid method (trial number: UMIN 000012780).…”

Section: Introductionmentioning

confidence: 99%

“…Fixation of the stranded seeds allows seed implantation outside the prostate capsule, while the planned position of each stranded seed is fixed and lacks flexibility. Several previous studies compared the dosimetric parameters between stranded and loose seeds 7–12 . We started the hybrid method using stranded seeds for the peripheral needles and loose seeds for the internal needles to maximize the strengths and minimize the limitations of each type of seed.…”

Section: Introductionmentioning

confidence: 99%

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Coverage of the external prostatic region by the hybrid method compared with the conventional method of prostate low‐dose‐rate brachytherapy: A randomized controlled study

et al. 2020

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Objectives: To compare the dose evaluation parameters between conventional (using loose seed alone) and hybrid (using loose seeds in combination with stranded seeds) low-dose rate brachytherapy for prostate cancer. Methods: Between 2014 and July 2016, a total of 219 patients who underwent lowdose rate brachytherapy were enrolled in a randomized controlled trial (trial number: UMIN 000012780). Patients were randomized and allocated to two groups (conventional method vs hybrid method). Post-dosimetric parameters (%D90, minimal percentage of the dose received by 90% of the prostate gland; V100, percentage of the prostate volume receiving 100% of the prescribed minimal peripheral dose; V150, percentage of the prostate volume receiving 150% of the prescribed minimal peripheral dose; %UD30, minimal percentage of the dose received by 30% of the urethra; R100, rectal volume [mL] receiving 100% of the prescribed dose) calculated at 1 month after seed implantation by computed tomography scan were compared between the two groups, as well as the post-dosimetric parameters using the planning target volume of the prostate + 5-mm margin. Results: Regarding dose evaluation parameters, the prostate dose (%D90, V100, V150) and the urethral dose (%UD30) were not significantly different between the two groups, whereas V100 (+5-mm margin) and %D90 (+5-mm margin) were significantly higher in the hybrid method group compared with the conventional method group (P < 0.001). Conclusion: The present randomized study shows that the hybrid method of low-dose rate brachytherapy can achieve a higher coverage of the periprostatic region compared with the conventional method while maintaining an acceptable level of urethral and rectal doses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Coverage of the external prostatic region by the hybrid method compared with the conventional method of prostate low‐dose‐rate brachytherapy: A randomized controlled study

et al. 2020

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“…Sources are available in a “loose” format as individual seeds or they can be linked, aka “stranded”, together at regular intervals (typically 1 cm) within surgical suture material ( Figure 3 ). Loose seeds can offer greater flexibility in seed spacing and may improve some post-implant dosimetric measures; however stranded seeds have a lower risk of migration outside of the peri-prostatic tissues and may result in better long-term dose coverage ( 36 - 38 ). Physicians often rely on their previous experience for selecting their source format, but both loose and stranded sources remain commonly used in modern prostate brachytherapy ( 29 ).…”

Section: Ldr Brachytherapy Sourcesmentioning

confidence: 99%

Low dose rate prostate brachytherapy

Stish¹,

Davis²,

Mynderse³

et al. 2018

Transl. Androl. Urol.

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Low dose rate (LDR) prostate brachytherapy is an evidence based radiation technique with excellent oncologic outcomes. By utilizing direct image guidance for radioactive source placement, LDR brachytherapy provides superior radiation dose escalation and conformality compared to external beam radiation therapy (EBRT). With this level of precision, late grade 3 or 4 genitourinary or gastrointestinal toxicity rates are typically between 1% and 4%. Furthermore, when performed as a same day surgical procedure, this technique provides a cost effective and convenient strategy. A large body of literature with robust follow-up has led multiple expert consensus groups to endorse the use of LDR brachytherapy as an appropriate management option for all risk groups of non-metastatic prostate cancer. LDR brachytherapy is often effective when delivered as a monotherapy, although for some patients with intermediate or high-risk disease, optimal outcome are achieved in combination with supplemental EBRT and/or androgen deprivation therapy (ADT). In addition to reviewing technical aspects and reported clinical outcomes of LDR prostate brachytherapy, this article will focus on the considerations related to appropriate patient selection and other aspects of its use in the treatment of prostate cancer.

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A review on permanent implants for prostate brachytherapy with comparison between stranded and loose seeds

Wei

Jiang

et al. 2021

Jpn J Radiol

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Loose versus stranded seeds in permanent prostate brachytherapy: Dosimetric comparison of intraoperative plans

Cited by 8 publications

References 31 publications

Coverage of the external prostatic region by the hybrid method compared with the conventional method of prostate low‐dose‐rate brachytherapy: A randomized controlled study

Coverage of the external prostatic region by the hybrid method compared with the conventional method of prostate low‐dose‐rate brachytherapy: A randomized controlled study

Low dose rate prostate brachytherapy

A review on permanent implants for prostate brachytherapy with comparison between stranded and loose seeds

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