Looping forward: exploring R‐loop processing and therapeutic potential
Kalliopi Stratigi,
Athanasios Siametis,
George A. Garinis
Abstract:Recently, there has been increasing interest in the complex relationship between transcription and genome stability, with specific attention directed toward the physiological significance of molecular structures known as R‐loops. These structures arise when an RNA strand invades into the DNA duplex, and their formation is involved in a wide range of regulatory functions affecting gene expression, DNA repair processes or cell homeostasis. The persistent presence of R‐loops, if not effectively removed, contribut… Show more
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