“…Long-duration spaceflight can result in the accumulation of IR exposures that may reach or exceed NASA career exposure limits (600 mSv weighted dose equivalent)—potentially producing both short- and long-term deleterious effects on human physiological systems that may limit mission success and increase risks of central nervous system (CNS) disruption, cardiovascular disease (CVD), and cancer morbidity/mortality in astronauts ( Cucinotta et al, 2001 ; Townsend, 2005 ; Cucinotta and Durante, 2006 ; Durante and Cucinotta, 2008 ; Rodman et al, 2017 ; Almeida-Porada et al, 2018 ; Onorato et al, 2020 ; Simonsen et al, 2020 ). Physical, biological, and pharmacological-based radiation protection and mitigation strategies will be required to ensure successful mission outcomes, complete with charged particle-specific radiation medical countermeasures (MCMs) that are easily administered, can safely be stored long-term and maintain efficacy, and show beneficial effects in multiple radiosensitive tissue compartments, e.g., the bone marrow (BM) niche and gastrointestinal (GI) tract ( Bokhari et al, 2022 ; DiCarlo et al, 2022 ).…”