Looking deeper than (just) below the surface

Looking deeper than (just) below the surface: response

“…First of all, bacteria cited in the paper (as stated in the discussion) do not play a significant role in postoperative endophthalmitis. 2 In addition, to understand the Disclosures: Michael Lawless is a member of the Medical Advisory Board Alcon LenSx USA.…”

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We thank the authors for their comment on our article 1 and their insight regarding the use of statistics, in particular Bayes theorem. 2 The recent increase and availability of ophthalmic research publications and the rise of evidencebased medicine means that expanding our understanding and application of appropriate study design and statistics is becoming essential for all practitioners within ophthalmology. For the majority of us, our current knowledge is unlikely to be adequate in most circumstances.This has been particularly highlighted by Lisboa et al in their recent analysis.

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Has the iridotomy 'worked'?: what the anterior segment OCT tells us

“…At risk of beating what is for us an old drum, we are not certain how many of the parameters for which the authors demonstrated a statistically significant difference with p ‐values – with a small sample and no adjustments – have clinical significance to patient care . Primary angle closure disease has a dynamic component, which may or may not be alleviated with an LPI .…”

“…3 At risk of beating what is for us an old drum, we are not certain how many of the parameters for which the authors demonstrated a statistically significant difference with p-valueswith a small sample and no adjustmentshave clinical significance to patient care. 5 Primary angle closure disease has a dynamic component, which may or may not be alleviated with an LPI. 6,7 Post-laser gonioscopy will tell us which angles have 'improved'; there are a number of angles which remain 'abnormal' after LPI, but we still lack a post-laser natural history to know whether these eyes remain at risk for angle closure complications.…”